Cell Death in the Thymus - It's All a Matter of Contacts
Apoptosis, or programmed cell death, plays a critical role in shaping the T cell repertoire, deleting unproductive as well as potentially autoreactive T cells. Our understanding of how thymocyte apoptosis is regulated is continually evolving, as new essential modulators of this process are discovered. A conundrum that remains, however, is how signaling through essentially the same receptors and cascades evokes distinct biological responses: death by neglect, positive or negative selection. We hypothesize that the immunological synapse (IS) may be critical to transducing survival signals during thymocyte development, and suggest that factors affecting IS assembly may also influence T cell selection.
Lisa Minter and B.A. Osborne. "Cell Death in the Thymus - It's All a Matter of Contacts" Seminars in Immunology 15.3 (2003): 135-144.
This document is currently not available here.