Before examining all of the different possible uses of distillers dried grains with solubles (DDGS), a discussion regarding ethanol and DDGS production methods is warranted. This chapter will cover current production processes and some of the new practices that have been developed and are being adopted at plants, including front-end fractionation and back-end fractionation. Additionally, standard coproduct definitions will be discussed, as they govern the marketing and sales of these materials.