Modern manufacturing systems continue to evolve and in so doing can produce many unique products using both traditional as well as novel raw materials. This is especially true in the processing of plastic products. In these environments, there is the need to critically examine material compatibility and to optimize methods of manufacture to realize economic success. Key to these endeavors is the ability to conduct product development efforts in a logical fashion. Experimentation is an important component to this process. Graduates of manufacturing engineering and technology programs should thus have knowledge of formal Design of Experiments (DOE) and statistical procedures. But, most undergraduate students are not exposed to these methodologies – only in graduate level statistics classes do engineering and technology students typically receive this type of training. Moreover, implementing formal, hands-on experiments can be problematic in many undergraduate curricula because they can be extremely time and resource consuming. Computer simulation can be one way to effectively implement and achieve these objectives, though. The goal of this paper is to describe how to use simulation software to conduct formal experiments using dedicated injection molding software. This paper will discuss several key topics, including a brief introduction regarding the teaching of statistics and DOE to engineering and technology students, as well as injection molding, a common manufacturing unit operation. An example simulation exercise will then be presented to illustrate the concepts discussed. Educators in manufacturing programs should find this useful as they consider how best to augment laboratory work, student understanding of statistics, as well as to achieve proficiency with computer simulation, as this approach to laboratory experiences transcends injection molding specifically, and has a wide range of applicability with many manufacturing operations.