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Article
Semantic Knowledge for Famous Names in Mild Cognitive Impairment
Journal of the International Neuropsychological Association (2009)
  • M Seidenberg
  • L Guidotti
  • Kristy Nielson, Marquette University
  • J L Woodard, Wayne State University
  • S Durgerian, Medical College of Wisconsin
  • Q Zhang, Medical College of Wisconsin
  • A Gander, Medical College of Wisconsin
  • M Franczak, Medical College of Wisconsin
  • P Antuono, Medical College of Wisconsin
  • S M Rao
Abstract

Person identification represents a unique category of semantic knowledge that is commonly impaired in Alzheimer’s disease (AD), but has received relatively little investigation in patients with mild cognitive impairment (MCI). The current study examined the retrieval of semantic knowledge for famous names from three time epochs (recent, remote, and enduring) in two participant groups: 23 amnestic MCI (aMCI) patients and 23 healthy elderly controls. The aMCI group was less accurate and produced less semantic knowledge than controls for famous names. Names from the enduring period were recognized faster than both recent and remote names in both groups, and remote names were recognized more quickly than recent names. Episodic memory performance was correlated with greater semantic knowledge particularly for recent names. We suggest that the anterograde memory deficits in the aMCI group interferes with learning of recent famous names and as a result produces difficulties with updating and integrating new semantic information with previously stored information. The implications of these findings for characterizing semantic memory deficits in MCI are discussed.

Publication Date
January, 2009
Citation Information
M Seidenberg, L Guidotti, Kristy Nielson, J L Woodard, et al.. "Semantic Knowledge for Famous Names in Mild Cognitive Impairment" Journal of the International Neuropsychological Association Vol. 15 (2009)
Available at: http://works.bepress.com/kristy_nielson/5/