Regulation of Hepatocyte Fate by Interferon-γ
Cytokine & Growth Factor Reviews, Volume 22, Issue 1, 35-43. DOI: 10.1016/j.cytogfr.2011.01.001
Interferon (IFN)-γ is a cytokine known for its immunomodulatory and anti-proliferative action. In the liver, IFN-γ can induce hepatocyte apoptosis or inhibit hepatocyte cell cycle progression. This article reviews recent mechanistic reports that describe how IFN-γ may direct the fate of hepatocytes either towards apoptosis or a cell cycle arrest. This review also describes a probable role for IFN-γ in modulating hepatocyte fate during liver regeneration, transplantation, hepatitis, fibrosis and hepatocellular carcinoma, and highlights promising areas of research that may lead to the development of IFN-γ as a therapy to enhance recovery from liver disease.
Christopher J. Horras, Cheri L. Lamb, and Kristen A. Mitchell. "Regulation of Hepatocyte Fate by Interferon-γ" Cytokine & Growth Factor Reviews 22.1 (2011): 35-43.
Available at: http://works.bepress.com/kristen_mitchell/32