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Article
Generating Long-Lasting ¹H and ¹³C Hyperpolarization in Small Molecules with Parahydrogen-Induced Polarization
Journal of Chemical Physics
  • Thorsten Jonischkeit
  • Ute Bommerich
  • Jorg Stadler
  • Klaus Woelk, Missouri University of Science and Technology
  • Heiko G. Niessen
  • Joachim Bargon
Abstract

Recently, Levitt and co-workers demonstrated that conserving the population of long-lasting nuclear singlet states in weak magnetic fields can lead to a preservation of nuclear spin information over times substantially longer than governed by the (high-field) spin-lattice relaxation time T1. Potential benefits of the prolonged spin information for magnetic resonance imaging and spectroscopy were pointed out, particularly when combined with the parahydrogen induced polarization (PHIP) methodology. In this contribution, we demonstrate that an increase of the effective relaxation time by a factor up to three is achieved experimentally, when molecules hyperpolarized by PHIP are kept in a weak magnetic field instead of the strong field of a typical NMR magnet. This increased lifetime of spin information makes the known PHIP phenomena more compatible with the time scales of biological processes and, thus, more attractive for future investigations.

Department(s)
Chemistry
Sponsor(s)
Center of Advanced Imaging (University of Magdeburg)
German Research Association
Keywords and Phrases
  • Nuclear Spin-Lattice Relaxation,
  • Polarisation,
  • Nuclear magnetic resonance,
  • Proton magnetic resonance
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2006 American Institute of Physics (AIP), All rights reserved.
Publication Date
5-1-2006
Publication Date
01 May 2006
Disciplines
Citation Information
Thorsten Jonischkeit, Ute Bommerich, Jorg Stadler, Klaus Woelk, et al.. "Generating Long-Lasting ¹H and ¹³C Hyperpolarization in Small Molecules with Parahydrogen-Induced Polarization" Journal of Chemical Physics Vol. 124 Iss. 20 (2006) ISSN: 0021-9606
Available at: http://works.bepress.com/klaus_woelk/31/