A university-community partnership assessed the food security and health status of food pantry participants in a midwestern urban community. Eighty percent of households surveyed were food insecure, and 40% experienced fair or poor health. The sample experienced higher rates of chronic disease than the general population. A nutrition education program designed to meet specific nutrition and health-related needs of pantry participants was developed. Implications include training pantry staff about chronic disease and its relationship to nutrition, identifying pantry foods that provide positive health benefits, and developing consumer publications focused on selecting and preparing pantry foods when one has chronic disease.