Associate Professor, Chemistry
My laboratory is interested in correlating structure-dynamics-function relationships in proteins utilizing an array of biochemical techniques and solution-state NMR spectroscopy. I have extensive expertise in the study of mutations of the cardiac membrane protein phospholamban (PLN), and the adipocyte lipid chaperone fatty acid binding protein 4 (FABP4). Students in my laboratory develop practical skills in recombinant protein expression, isolation, and characterization.
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About Kim N. Ha, PhD
My laboratory is interested in correlating structure-dynamics-function relationships in proteins utilizing an array of biochemical techniques and solution-state NMR spectroscopy. I have extensive expertise in the study of mutations of the cardiac membrane protein phospholamban (PLN), and the adipocyte lipid chaperone fatty acid binding protein 4 (FABP4). Students in my laboratory develop practical skills in recombinant protein expression, isolation, and characterization.
| 2018 - Present | Associate Professor, St. Catherine University ‐ Department of Chemistry and Biochemistry | |
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| 2012 - 2018 | Assistant Professor, St. Catherine University ‐ Department of Chemistry and Biochemistry | |
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Disciplines
Research Interests
Grants
| 2018 - Present | Structural Basis of Dilated Cardiomyopathy |
| National Heart Lung and Blood Institute - 5R01HL144130 | |
| Role: Collaborator | |
| 2019 - 2020 | Measuring the structural dynamics of Hox family transcription factor lin-39 and its mutant lin-39(ccc16) in complex with mab-5 and DNA using NMR spectroscopy. |
| Summer Scholars Program | |
| Role: Co-PI | |
| Colleague(s): Dr. Andrea Kalis, Biology | |
| 2019 - 2019 | Hox protein function in patterning C. elegans neuronal cell fates |
| Small 3M Collaborative Research Grant | |
| Role: Co-PI | |
| Colleague(s): Dr. Andrea Kalis, Biology | |
| 2018 - 2019 | Determining the Impact of Domain Ib Mutations of Phospholamban on Phosphorylation and SERCA Regulation |
| Summer Scholars Program | |
| Role: PI | |
| 2017 - 2018 | Characterizing Dynamics-Driven Ligand Selection of Adipocyte Fatty Acid Binding Protein |
| APDC Faculty Scholarship Award | |
| Role: PI | |
| 2016 - 2017 | Characterization of Dilated Cardiomyopathy Linked R25 Mutations of Phospholamban |
| Clare Boothe Luce Collaborative Research Award | |
| Role: PI | |
| 2012 - 2016 | Phase Forward: Turning Obstacles into Opportunities |
| National Science Foundation S-STEM Program | |
| Role: Co-PI | |
| 2015 - 2015 | Console upgrade of 600 MHz NMR Spectrometer |
| Office of the Director, National Institutes of Health | |
| Shared Instrumentation Grant | |
| Role: Co-PI | |
| 2014 - 2015 | NMR Resonance Assignment of Fatty Acid Binding Protein-4 |
| Summer Scholars Program | |
| Role: PI | |
| 2014 - 2015 | Pushing the limits of rational design in therapeutic phospholamban mutants through optimizing dephosphorylation by protein-phosphatase 1 |
| Large 3M Collaborative Research Grant | |
| Role: PI | |
| 2013 - 2014 | Dephosphorylation on Therapeutic Mutants of the Cardiac Protein Phospholamban |
| Clare Booth Luce Collaborative Research Award | |
| Role: PI | |
| 2009 - 2012 | Rational Design of Loss-of-Function Phospholamban Mutants for Gene Therapy |
| National Heart Lung and Blood Institute - F31HL095361 | |
| Role: Fellow |
Professional Service and Affiliations
| 2017 - Present | Member, Committee of Inclusion and Diversity, Biophysical Society | 2012 - Present | Vice President, Iota Sigma Pi Mercury Chapter | 2018 - 2020 | Co-chair, University Faculty Evaluation Promotion and Tenure Committee (UFEPT) | 2017 - 2018 | President, Midwest Association of Chemistry Teachers at Liberal Arts Colleges (MACTLAC) |
Honors and Awards
- Minnesota Medical Foundation. (2012). Dr. Marvin and Hassedeh Bacaner Award for creativity in biomedical research
- Department of Biochemistry, Molecular Biology, and Biophysics - University of Minnesota. (2011). Ross A. Gortner Award for excellence in protein chemistry and enzymology research.
- Department of Biochemistry, Molecular Biology, and Biophysics - University of Minnesota. (2011). Beatrice Z. Milne and Theodore Brandenburg Award for Excellence in Graduate Thesis Research
- Department of Biochemistry, Molecular Biology, and Biophysics - University of Minnesota. (2011). Cyrus Barnum Teaching Award
- College of Biological Sciences - University of Minnesota. (2011). Teaching Assistant of the Year Award, Finalist
- National Heart Lung and Blood Institute, NIH. (2008). Ruth Kirschstein National Research Service Award Predoctoral Fellowship
- Department of Biochemistry, Molecular Biology, and Biophysics - University of Minnesota (2012). Armstrong Pothapragada Award in Biochemistry
Courses
| 2012 | Ph.D., Biochemistry, University of Minnesota - Twin Cities | |
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| 2007 | Master of Science, Chemistry, University of Minnesota - Twin Cities | |
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| 2004 | Bachelor of Arts, Chemistry, University of Minnesota - Twin Cities | |
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Contact Information
St. Catherine University
2004 Randolph Avenue
St. Paul, MN 55105
651-690-8617
Email: