Skip to main content
Article
Generation of Novel Pikromycin Antibiotic Products Through Mutasynthesis
Chemistry Faculty Publications and Presentations
  • Shuchi Gupta, Portland State University
  • Venkatraman Lakshmanan, University of Minnesota - Twin Cities
  • Beom Seok Kim, Portland State University
  • Robert Fecik, University of Minnesota - Twin Cities
  • Kevin A. Reynolds, Portland State University
Document Type
Post-Print
Publication Date
1-1-2009
Subjects
  • Antibiotics -- Metabolism,
  • Macrolide antibiotics,
  • Polyketide synthases,
  • Polyketides -- Synthesis,
  • Anti-infective agents
Abstract

Mutasynthesis in pikromycin PKS: The amenability of pikromycin polyketide synthase to mutational biosynthesis has been demonstrated. A natural triketide and its analogues, activated as N-acetyl-cysteamine thioesters, were synthesized and fed to a pikAI-deleted strain; this led to the production of new antibiotics. A vinyl analogue was found to have better antibacterial activity than pikromycin.

Description

this is the author’s version of a work that was accepted for publication in ChemBioChem. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in ChemBioChem, 9: 1609–1616 and is available online at: https://doi.org/10.1002/cbic.200700635

DOI
10.1002/cbic.200700635
Persistent Identifier
http://archives.pdx.edu/ds/psu/19067
Citation Information
Shuchi Gupta, Venkatraman Lakshmanan, Beom Seok Kim, Robert Fecik, et al.. "Generation of Novel Pikromycin Antibiotic Products Through Mutasynthesis" (2009)
Available at: http://works.bepress.com/kevin-reynolds/15/