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Dynamic Passivation with BSA Overcomes LTCC Mediated Inhibition of PCR (with Jason Besecker and Greg Hampikian), Sensors and Actuators B: Chemical (2013)
The increasing use of low temperature co-fired ceramic (LTCC) for the fabrication of biological microfluidic...
Methylthioadenosine/S-adenosylhomocysteine Nucleosidase, a Critical Enzyme for Bacterial Metabolism (with Nikhat Parveen), Molecular Microbiology (2011)
The importance of methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase in bacteria has started to be appreciated only in...
Optimizing Luciferase Reporter Vector Transfection in 5L Rat Hepatoma Cells (with Emily Calton, Reilly Clark, Ricky Aguayo, Jonathan Walsh, Cheri Lamb, Henry Charlier, and Kristen Mitchell), IDeA Network for Biomedical Research Excellence (INBRE) (2010)
Signal transducer and activator of transcription (STAT) 1 is a transcription factor activated by the...
Transfection of Luciferase Gene into 5L Cells to Monitor STAT Activation (with Andria Wellman, Christie Hammons, Robert Cox, Stephanie Saylor, Cheri L. Lamb, Henry Charlier, and Kristen A. Mitchell), IDeA Network for Biomedical Research Excellence (INBRE) (2010)
The cytokine interferon gamma (IFNγ) is a small, secreted protein that binds to its cognate...
Finding MRSA’s Kryptonite: Computational Directed Combatant Pentapeptides (with Reed B. Jacob and Owen M. McDougal), 90th Annual Meeting of the Pacific Division of the American Association for the Advancement of Science (2009)
Structural Basis for α-Conotoxin Potency and Selectivity (with Matt Turner, Seth Eidemiller, Bryan Martin, Andrew Narver, Joshua Marshall, and Owen M. McDougal), Bioorganic & Medicinal Chemistry (2009)
Parkinson’s disease is a debilitating movement disorder characterized by altered levels of α6β2* nicotinic acetylcholine...
Assessment of methylthioadenosine/S-adenosylhomocysteine nucleosidases of Borrelia burgdorferi as Targets for Novel Antimicrobials Using a Novel High-Throughput Method (with Shekerah Primus, Jorge A. Martinez, and Nikhat Parveen), Journal of Antimicrobial Chemotherapy (2009)
Background: Lyme disease is the most prevalent tick-borne disease in the USA with the highest...
Molecular Determinants of Substrate Specificity in Plant 5′-Methylthioadenosine Nucleosidases (with Karen K.W. Siu, Jeffrey E. Lee, Janice R. Sufrin, Barbara A. Moffatt, Martin McMillan, Chelsea Isom, and P. Lynne Howell), Journal of Molecular Biology (2008)
5′-Methylthioadenosine (MTA)/S-adenosylhomocysteine (SAH) nucleosidase (MTAN) is essential for cellular metabolism and development in many bacterial...
Structure of Arabidopsis thaliana 5-methylthioribose kinase Reveals a More Occluded Active Site Than Its Bacterial Homolog (with Shao Yang-Ku and P. Lynne Howell), BMC Structural Biology (2007)
Background: Metabolic variations exist between the methionine salvage pathway of humans and a number of...
OsMTN Encodes a 5′-methylthioadenosine Nucleosidase that is Up-Regulated During Submergence-Induced Ethylene Synthesis in Rice (Oryza sativa L.) (with Guillaume Rzewuski, Lee Rooney, Katharina Bürstenbinder, Markus Wirtz, Rüdiger Hell, and Margret Sauter), Journal of Experimental Botany (2007)
Methylthioadenosine (MTA) is released as a by-product of S-adenosylmethionine (AdoMet)-dependent reactions central to ethylene,...
Structural Snapshots of MTA/AdoHcy Nucleosidase Along the Reaction Coordinate Provide Insights into Enzyme and Nucleoside Flexibility During Catalysis (with Jeffrey E. Lee, G. David Smith, Cathy Horvatin, David J.T. Huang, Michael K. Riscoe, and P. Lynne Howell), Journal of Molecular Biology (2005)
MTA/AdoHcy nucleosidase (MTAN) irreversibly hydrolyzes the N9-C1′ bond in the nucleosides, 5′-methylthioadenosine (MTA) and S-adenosylhomocysteine...