Anaesthesia
The respiratory depressant effect of morphine: a comparative study in three ethnic groups, Anaesthesia (1994)
The respiratory response to carbon dioxide was measured in 130 ASA 1 adult male patients...
Pharmacokinetics of Flumazenil and Midazolam in Paediatric Patients, British Journal of Anaesthesia (1993)
We have studied simultaneously the pharmacokinetics of flumazenil and midazolam in 12 healthy Chinese children,...
Disposition of Propofol at Caesarean Section and in the Postpartum Period, British Journal of Anaesthesia (1991)
We have compared the pharmacokinetics of a bolus dose of propofol 2 mg kg-1 in...
Disposition of Propofol Infusions for Caesarean Section, Canadian Journal of Anaesthesia (1991)
The disposition of propofol was studied in women undergoing elective Caesarean section. Indices of maternal...
Effect of Adrenaline on Venous Plasma Concentrations of Bupivacaine after Interpleural Administration, British Journal of Anaesthesia (1990)
Bupivacaine 2.5 mg kg-1 (0.5 ml kg-1 of 0.5% solution), with or without adrenaline 5...
Maternal and Fetal Levels of Propofol at Caesarean Section, Anaesthesia and Intensive Care (1990)
Twenty women were given a bolus induction of propofol 2.0 mg.kg-1 for elective caesarean section....
Pharmacokinetics of Propofol in Children, British Journal of Anaesthesia (1990)
The pharmacokinetics of propofol were studied in 12 healthy Chinese children, aged 4-12 yr, undergoing...
Pharmacokinetics of Propofol in Women Undergoing Elective Caesarean Section, British Journal of Anaesthesia (1990)
We have compared the pharmacokinetics of a bolus induction dose of propofol 2 mg kg-1...
Propofol Infusion Anaesthesia for Caesarean Section, Canadian Journal of Anaesthesia (1990)
Two propofol infusion regimens and a standard general anaesthetic were compared in thirty Chinese women...
A Comparison of Alfentanil Requirements in European and Asian Patients During General Anaesthesia, Anaesthesia and Intensive Care (1988)
Alfentanil requirements were compared in thirty-six Asian and forty-three European patients during general anaesthesia with...
Elimination of Phenoperidine in Liver Disease, British Journal of Anaesthesia (1984)
The disposition and elimination of phenoperidine was studied in five normal subjects, and in six...
Effect of Antacids on the Plasma Concentration of Phenoperidine, British Journal of Anaesthesia (1983)
The effect of antacids on the plasma concentration of phenoperidine was studied in six volunteers....
Plasma Concentration of Pyridostigmine During the Antagonism of Neuromuscular Block, British Journal of Anaesthesia (1982)
The plasma concentrations of pyridostigmine were measured in eight patients during the antagonism of non-depolarizing...
Plasma Concentration and Metabolism of Phenoperidine in Man, British Journal of Anaesthesia (1980)
The plasma concentrations of phenoperidine were measured in five patients during general anaesthesia. The concentration...
Chinese Medicine
Astragalus Saponins Induce Growth Inhibition and Apoptosis in Human Colon Cancer Cells and Tumor Xenograft, Carcinogenesis (2007)
Astragalus memebranaceus is used as immunomodulating agent in treating immunodeficiency diseases and to alleviate the...
Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tactrine, a promising anti-Alzheimer's dimer, in rat blood, Journal of Pharmaceutical and Biomedical Analysis (2007)
An analytical method using on-line high performance liquid chromatography-tandem mass spectrometry with electrospray ionization was...
Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells, Federation of European Biochemical Societies Letters (2006)
We here provide definitive evidence that ginsenoside- Rg1, the pharmacologically active component of ginseng, is...
Simultaneous Qualitative and Quantitative Analyses of the Major Constituents in the Rhizome of Ligusticum Chuanxiong Using HPLC-DAD-MS, Chemical & Pharmaceutical Bulletin (2006)
An HPLC-DAD-MS method was developed for the qualitative and quantitative analysis of the major constituents...
The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model, Journal of Ethno-Pharmacology (2006)
Paeoniflorin and sinomenine, derived from the root of Paeonia lactiflora Pall. (family Ranunculaceae) and the...
Building a Bridge for Integrating Chinese Medicine into Conventional Healthcare: Observations Drawn from the Development of the Chinese Quality of Life Instrument (Li Zhao and Kelvin Chan) (with Li Zhao), The American Journal of Chinese Medicine (2005)
This paper describes the methods and theories of patient-reported outcomes, in particular to the health-related...
Assay of free ferulic acid and total ferulic acid for the quality assessment of Angelica Sinensis, Journal of Chromatography A (2005)
Activity of Chinese Danggui (DG), the processed root of Angelica sinensis (Oliv.) Diels, is linked...
Chinese Medicinal Materials and their Interface with Western Medical Concepts, Journal of Ethno-Pharmacology (2005)
Chinese medicine (CM), one of the oldest continuously surviving traditions, has been practised to maintain...
Development and Validation of the Chinese Quality of Life Instrument, Health and Quality of Life Outcomes (2005)
Background: This paper describes the development of the Chinese Quality of Life Instrument (ChQOL) which...
Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg1 in vivo and in vitro, Angiogenesis (2005)
The major active constituents of ginseng are ginsenosides, and Rg1 is a predominant compound of...
Systematic Evaluation of Organochlorine Pesticide Residues in Chinese Materia Medica, Phytotherapy Research (2005)
A systematic evaluation on the levels of organochlorine pesticide residues (OCP) was conducted on four...
The Effects of a Chinese Medicinal Suppository (Vitalliver) on Insulin-like Growth Factor 1 and Homocysteine in Patients with Hepatitis B Infection, Phytotherapy Research (2005)
The liver is the major organ for the metabolism of homocysteine (Hcy) and production of...
A Panel Study on the Effects of a Chinese Medicinal Suppository, Vigconic VI-28, on Insulin-like Growth Factor 1 and Homocysteine in Healthy Men, Methods & Findings in Experimental & Clinical Pharmacology (2004)
Changes in serum homocysteine (Hcy), often related to stroke and vascular dementia, are negatively correlated...
Application of Factor Analysis in Development and Validation of A New Questionnaire for Quality of Life (in Chinese), Chinese Journal of Integrated & Western Medicine (2004)
Objective: To explore the application of factor analysis in creating a new health—related questionnaire for...
Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction, Life Sciences (2004)
Homocysteine (Hcy) is a by-product of methionine metabolism. An imbalance of Hcy in the body...
Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatography-mass spectometry, Journal of Chromatography A (2004)
A reversed phase high-performance liquid chromatographic method was developed for quantifying E-ligustilide (1) and Z-ligustilide...
Quality of Life Assessment : an Outcome Estimation of Chinese Medical Treatment, Chinese Journal of Integrative Medicine (2003)
At present, quality of life (QOL) has become a relevant measure of efficacy in clinical...
Some aspects of toxic contaminants in herbal medicines, Chemosphere (2003)
A World Health Organisation survey indicated that about 70-80% of the world populations rely on...
Danggui (Angelica Sinensis) affects the pharmacodynamics but not the pharmacokinetics of warfarin in rabbits, European Journal of Drug Metabolism and Pharmacokinetics (1995)
Danggui is a popular traditional Chinese medicinal (TCM) herb which is easily obtained by the...
The effects of of Danshen (salvia miltiorrhiza) on pharmacokinetics and pharmacodynamics of warfarin in rats, European Journal of Drug Metabolism and Pharmacokinetics (1992)
Danshen is a Chinese folk medicine commonly used in the Chinese population. The effects of...
Modern Antimalarial Drug Therapy in Southeast Asia and China: A Symposium Report, Drugs of Today (1988)
One of the highlights of the scientific program of the 1st Scientific Meeting of the...
Herbal Medicines
Simultaneous Qualitative and Quantitative Analyses of the Major Constituents in the Rhizome of Ligusticum Chuanxiong Using HPLC-DAD-MS, Chemical & Pharmaceutical Bulletin (2006)
An HPLC-DAD-MS method was developed for the qualitative and quantitative analysis of the major constituents...
Building a Bridge for Integrating Chinese Medicine into Conventional Healthcare: Observations Drawn from the Development of the Chinese Quality of Life Instrument (Li Zhao and Kelvin Chan) (with Li Zhao), The American Journal of Chinese Medicine (2005)
This paper describes the methods and theories of patient-reported outcomes, in particular to the health-related...
Systematic Evaluation of Organochlorine Pesticide Residues in Chinese Materia Medica, Phytotherapy Research (2005)
A systematic evaluation on the levels of organochlorine pesticide residues (OCP) was conducted on four...
Quality Control of Herbal Medicines, Journal of Chromatography B (2004)
Different chromatographic and electrophoretic techniques commonly used in the instrumental inspection of herbal medicines (HM)...
Some aspects of toxic contaminants in herbal medicines, Chemosphere (2003)
A World Health Organisation survey indicated that about 70-80% of the world populations rely on...
Pharmacokinetics, Biochemistry
Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer’s dimer bis(7)-tacrine, International Journal of Pharmaceutics (2008)
The present study aims to investigate the preclinical intestinal absorption of bis(7)-tacrine (B7T) using different...
Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tactrine, a promising anti-Alzheimer's dimer, in rat blood, Journal of Pharmaceutical and Biomedical Analysis (2007)
An analytical method using on-line high performance liquid chromatography-tandem mass spectrometry with electrospray ionization was...
Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells, Federation of European Biochemical Societies Letters (2006)
We here provide definitive evidence that ginsenoside- Rg1, the pharmacologically active component of ginseng, is...
Assay of free ferulic acid and total ferulic acid for the quality assessment of Angelica Sinensis, Journal of Chromatography A (2005)
Activity of Chinese Danggui (DG), the processed root of Angelica sinensis (Oliv.) Diels, is linked...
Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg1 in vivo and in vitro, Angiogenesis (2005)
The major active constituents of ginseng are ginsenosides, and Rg1 is a predominant compound of...
Influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in unrestrained conscious rats, Journal of Ethno-Pharmacology (2005)
Paeonia lactiflora Pall. (Ranunculaceae) root and Sinomenium acutum Rehder and Wilson (Menispermaceae) stem are two...
In Vitro Protein Binding Characteristics of Isoniazid, Rifampicin and Pyrazinamide to Whole Plasma, Albumin, and α-1-Acid Glycoprotein, Clinical Biochemistry (1996)
The study of protein binding of anti-tuberculous drugs is of clinical interest, since the degree...
Danggui (Angelica Sinensis) affects the pharmacodynamics but not the pharmacokinetics of warfarin in rabbits, European Journal of Drug Metabolism and Pharmacokinetics (1995)
Danggui is a popular traditional Chinese medicinal (TCM) herb which is easily obtained by the...
Measuring the Nandralone Threshold Ratio by Enzyme-Linked Immunosorbent Assay for 5α-estrane-3β,17α-diol, Analytica Chimica Acta (1993)
The international threshold for nandrolone in equine urine is reached when the ratio of 5α-estrane-3β,17α-diol...
Pharmacokinetics of Flumazenil and Midazolam in Paediatric Patients, British Journal of Anaesthesia (1993)
We have studied simultaneously the pharmacokinetics of flumazenil and midazolam in 12 healthy Chinese children,...
Disposition of Epirubicin in an oily contrast medium after intravenous and intrahepato-arterial administration in liver cancer: a preliminary report, European Journal of Drug Metabolism and Pharmacokinetics (1992)
The present study reports findings on the disposition of epirubicin after an intrahepato-arterial administration of...
The effects of of Danshen (salvia miltiorrhiza) on pharmacokinetics and pharmacodynamics of warfarin in rats, European Journal of Drug Metabolism and Pharmacokinetics (1992)
Danshen is a Chinese folk medicine commonly used in the Chinese population. The effects of...
The use of a packed column for the determination of bupivacaine in human plasma by gas chromatography: an application in a pharmacokinetic study of bupivacaine, Forensic Science International (1992)
The method involves a single extraction of the drug and the internal standard, etidocaine, from...
Ephedrine and Phenylpropanolamine Potentiate the Lethal Toxicity of Morphine and Codeine in Naive Mice, Asia Pacific Journal of Pharmacology (1991)
The effects of ephedrine and phenylpropanolamine, (PPA) on the acute lethal toxicity of morphine and...
Effect of Adrenaline on Venous Plasma Concentrations of Bupivacaine after Interpleural Administration, British Journal of Anaesthesia (1990)
Bupivacaine 2.5 mg kg-1 (0.5 ml kg-1 of 0.5% solution), with or without adrenaline 5...
Effects of Ephedrine and Phenylpropanolamine on the Antinociceptive Effects of Morphine and Codeine in Mice, Archives Internationales de Pharmacodynomie et de Thérapie (1990)
The effects of ephedrine and phenylpropanolamine on the antinociceptive activities of morphine and codeine were...
Improved gas chromatographic method for the quantitation of plasma pethidine and norpethidine: application in determining pharmacokinetic parameters in Chinese patients after intramuscular administration of pethidine, Journal of Biopharmaceutical Sciences (1990)
A sensitive and accurate gas liquid chromatographic (GLC) method is described to determine pethidine and...
Maternal and Fetal Levels of Propofol at Caesarean Section, Anaesthesia and Intensive Care (1990)
Twenty women were given a bolus induction of propofol 2.0 mg.kg-1 for elective caesarean section....
Pharmacokinetics and pharmacodynamics of subcutaneous and intraperitoneal administration of recombinant human erythropoietin in patients on continuous ambulatory peritoneal dialysis, Clinical Nephrology (1990)
The single-dose pharmacokinetics of 50 U/kg body weight of recombinant human erythropoietin (rHuEPO) given by...
Pharmacokinetics of Propofol in Children, British Journal of Anaesthesia (1990)
The pharmacokinetics of propofol were studied in 12 healthy Chinese children, aged 4-12 yr, undergoing...
Pharmacokinetics of Propofol in Women Undergoing Elective Caesarean Section, British Journal of Anaesthesia (1990)
We have compared the pharmacokinetics of a bolus induction dose of propofol 2 mg kg-1...
Propofol Infusion Anaesthesia for Caesarean Section, Canadian Journal of Anaesthesia (1990)
Two propofol infusion regimens and a standard general anaesthetic were compared in thirty Chinese women...
Disposition of ethmozine in cerebrospinal fluid and plasma of rabbits, European Journal of Drug Metabolism and Pharmacokinetics (1989)
The concentration-time profiles of ethmozine, a newly introduced anti-arrhythmic drug, in the cerebrospinal fluid (CSF)...
Physicochemical Properties and Buccal Absorption of Ethmozine, Asia Pacific Journal of Pharmacology (1989)
The pKa value, partition coefficients between n-heptane-, octanol- and dichloromethane- phosphate buffer, and buccal absorption...
A Comparison of Alfentanil Requirements in European and Asian Patients During General Anaesthesia, Anaesthesia and Intensive Care (1988)
Alfentanil requirements were compared in thirty-six Asian and forty-three European patients during general anaesthesia with...
Determination of Alfentanil in Human Plasma Using Gas Liquid Chromatography with Capillary Column and Nitrogen Selective Detection, Asia Pacific Journal of Pharmacology (1988)
A gas liquid chromatography (GLC) for the determination of alfentanil in plasma of surgical patients...
Modern Antimalarial Drug Therapy in Southeast Asia and China: A Symposium Report, Drugs of Today (1988)
One of the highlights of the scientific program of the 1st Scientific Meeting of the...
Peptides as Targets for Drug Research, Drugs of Today (1988)
In a residential Symposium on "Peptides as Targets for Drug Research" at Vanbrugh College, University...
pharmacokinetics of pyrazinamide in plasma and CSF of rabbits following intravenous and oral administration, European Journal of Drug Metabolism and Pharmacokinetics (1988)
The pharmacokinetics of pyrazinamide (PZA) in cerebrospinal fluid (CSF) and plasma of 10 rabbits were...
Pyrazinamide and Rifampicin Regimens for Patients on Maintenance Dialysis, The International Journal of Artificial Organs (1988)
We measured pyrazinamide and rifampicin plasma concentrations in five patients with pulmonary tuberculosis and end...
Cerebrospinal fluid and serum levels of pyrazinamide and rifampicin in patients with tuberculous meningitis, Current Therapeutic Research (1987)
Using a high performance liquid chromatography assay, pyrazinamide and rifampicin concentrations were measured in paired...
A simultaneous determination of rifampin and 25-desacetylrifampin in cerebrospinal fluid and plasma of rabbit by Iiquid chromatography, Acta Pharmacologica Sinica (1987)
A liquid chromatographic assay was modified for the simultaneous determination of rifampin (R) and its...
Pharmacokinetics of Pyrazinamide in CSF and Plasma of Rabbits: Influence of Anaesthesia, Asia Pacific Journal of Pharmacology (1987)
The influence of anaesthesia on the pharmacokinetics of pyrazinamide (PZA) in cerebrospinal fluid (CSF) and...
Anti-Tuberculous Drug Penetration into Cerebrospinal Fluid in a Rabbit Model, Asia Pacific Journal of Pharmacology (1986)
The concentration-time profiles of rifampicin and pyrazinamide in the cerebrospinal fluid (CSF) and plasma of...
High performance liquid chromatographic characterisation and quantitation of p-aminobenzoic acid N-acetylation in Chinese subjects, European Journal of Drug Metabolism and Pharmacokinetics (1986)
p-Aminobenzoic acid (PABA), p-acetamidobenzoic acid (PADB) and p-aminohippuric acid (PAH) have been separated and determined...
Elimination of Phenoperidine in Liver Disease, British Journal of Anaesthesia (1984)
The disposition and elimination of phenoperidine was studied in five normal subjects, and in six...
The effect of incorporation of indomethacin with polyethylene glycol 6000 in a solid dispersion on its in vivo properties in the rat, Agents and Actions (1984)
Preparations of indomethacin and indomethacin in combination with PEG 6000 were administered in solid form...
Effect of Antacids on the Plasma Concentration of Phenoperidine, British Journal of Anaesthesia (1983)
The effect of antacids on the plasma concentration of phenoperidine was studied in six volunteers....
Effect of Urine pH on the Elimination of Phenoperidine, British Journal of Clinical Pharmacology (1983)
The effect of urine pH ont he plasma concentration and elimination of phenoperidine and its...
Plasma Concentration of Pyridostigmine During the Antagonism of Neuromuscular Block, British Journal of Anaesthesia (1982)
The plasma concentrations of pyridostigmine were measured in eight patients during the antagonism of non-depolarizing...
Plasma Concentration and Metabolism of Phenoperidine in Man, British Journal of Anaesthesia (1980)
The plasma concentrations of phenoperidine were measured in five patients during general anaesthesia. The concentration...
Pharmacokinetics and Pharmacological Effects of Neostigmine in Man, British Journal of Clinical & Hospital Pharmacology (1979)
1 The pharmacokinetics of neostigmine was studied in six patients during the reversal of neuromuscular...
Clearance of Neostigmine from the Circulation During the Antagonism of Neuromuscular Block, British Journal of Anaesthesia (1978)
The plasma concentration of neostigmine was measured in five patients during the antagonism of neuromuscular...
Plasma Clearance of Neostigmine and Pyridostigmine in the Dog, British Journal of Pharmacology (1978)
1. The pharmacokinetics of neostigmine and pyridostigmine was studied in conscious dogs by the use...
Plasma Concentration of Pyridostigmine and Effects in Myasthenia Gravis, Clinical Pharmacology and Therapeutics (1978)
The relation between the plasma concentration of pyridostigmine and its effects was studied in 5...
Plasma Pyridostigmine Levels in Patients with Myasthenis Gravis, Clinical Pharmacology and Therapeutics (1977)
Plasma concentrations of pyridostigmine were measured in 7 patients with myasthenia gravis. Six subjects on...
Renal Clearance of Pyridostigmine in Patients with Myasthenia gravis, European Neurology (1977)
The urinary clearance of pyridostigmine was studied in six patients with myasthenia gravis. In three...
The Effect of Ageing on Plasma Pethidine Concentration, British Journal of Clinical Pharmacology (1975)
1. Plasma pethidine levels have been monitored after the administration of 1.5 mg/kg intramuscularly to...
The Effect of Ageing on Plasma Pethidine Concentration, British Journal of Clinical & Hospital Pharmacology (1975)
1. Plasma pethidine levels have been monitored after the administration of 1.5 mg/kg intramuscularly to...
No subject area
The Chinese Quality Of Life Instrument: Development Of A New Health-Related Quality Of Life Instrument Using Factor Analysis And Structural Equation Modeling (with Li Zhao, Kwok-fai Leung, Feng-bin Liu, Jian-ying Lang, and Ji-qian Fang), Journal of Complementary and Integrative Medicine (2005)
A new Chinese Quality of Life Instrument (ChQOL) based on the principles of diagnosis and...
Regulatory System of Proprietary Chinese Medicine in Hong Kong (with Kelvin Sze-Yin Leung), Journal of Complementary and Integrative Medicine (2004)
Traditional medicine has been used by a significant percentage of the population not only in...
Biotransformation of pethidine: a comparative study of 24 h urine in three ethnic groups, European Journal of Drug Metabolism and Pharmacokinetics (1993)
219 surgical patients of either Caucasian, Chinese or Nepalese origin were given pethidine 1 mg/kg...