Kathryn Splan is an inorganic and biochemist with a background in porphyrin
chemistry and medicinal biochemistry. She arrived at Macalester in the Fall of 2007 and
teaches in both the biochemistry and introductory chemistry sequences. Her current
research focuses on Inhibitor of Apoptosis Proteins (IAPs), which play a key role in the
control of programmed cell death. Specifically, her current work focuses on the
development and characterization multivalent peptide inhibitors that target IAPs and
explores the metal binding properties of IAPs from a bioinorganic and biophysical
perspective. Prof. Splan is excited to pursue her varied research interests alongside
Macalester students with interests at the interface of Chemistry and Biology. 

Splan's dissertation, Development and Characterization of Porphyrin Chromophores for
Solar Energy Conversion, focuses on the synthesis and fundamental photophysical and
photoelectrochemical properties of porphyrin compounds in the context of solar energy

Her postdoctoral work at Duke University and the University of Minnesota was broadly
focused on protein chemistry. Her current interests include the characterization of
peptide-protein interactions and the metal-binding properties of apoptotic proteins
involved in cell-death pathways. 

EDUCATION: B.S., University of Wisconsin, Eau Claire Ph.D., Northwestern University 

Splan has been teaching at Macalester since 2007. 



Copper-binding Properties of the BIR2 and BIR3 Domains of the X-linked Inhibitor of Apoptosis Protein (with Yiwen Liang, Patrick M. Ewing, Willem J. Laursen, Valerie T. Tripp, and Subha Singh), Journal of Inorganic Biochemisty (2014)


Spectroscopic Characterization of Copper(I) Binding to Apo and Metal-Reconstituted Zinc Finger Peptides (with R. T. Doku, G. Park, and K. E. Wheeler), JBIC Journal of Biological Inorganic Chemistry (2013)


Photophysical Investigation of Neutral and Diprotonated Free-base Bis(Arylethynyl)-porphyrins (with P. K. Goldberg and T. J. Pundsack), Journal of Physical Chemistry A (2011)


In vitro assays for the determination of aminoacyl-tRNA synthetase editing activity (with Karin Musier-Forsyth and Michal T. Boniecki), Methods (2008)