Objectives: To introduce the readers to the field of injury prevention and comprehensive public health intervention approaches. Methods: A review of injury epidemiology, statistics, definitions, intervention approaches, and the importance of health promotion is provided. Results: Behavioral, environmental, and technological solutions will be necessary to reduce or eliminate the factors that lead to injury. Conclusions: Reductions in injury and their costs will need the support, collaboration, and partnering of several disciplines. The use of sound behavioral and social science theories and methods will be an essential component of intervention effectiveness.