Articles

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Osteochondritis Dissecans Knee Histology Studies Have Variable Findings and Theories of Etiology (with Kevin G. Shea, John C. Jacobs Jr., James L. Carey, and Allen F. Anderson), Clinical Orthopaedics and Related Research (2013)

Background

Although many etiological theories have been proposed for osteochondritis dissecans (OCD), its etiology remains...

 

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Minor Fibrillar Collagens, Variable Regions Alternative Splicing, Intrinsic Disorder, and Tyrosine Sulfation (with Ming Fang, Reed B. Jacob, and Owen McDougal), Protein & Cell (2012)

Minor fibrillar collagen types V and XI, are those less abundant than the fibrillar collagens...

 

Predicted Structure and Binding Motifs of Collagen a1(Xi) (with Owen McDougal, Lisa Warner, and Chris Mallory), Journal on Bioinformatics and Biotechnology (2011)

The amino propeptide of collagen a1(XI) (NPP) has been shown to bind glycosaminoglycans and to...

 

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Proteomic Analysis of Col11a1-associated Protein Complexes (with Raquel Brown, Christopher Mallory, and Owen M. McDougal), Proteomics (2011)

Cartilage plays an essential role during skeletal development within the growth plate and in articular...

 

Collagen Type XI α1 Chain Amino Propeptide Structural Model and Glycosaminoglycan Interactions in Silico (with Christopher Mallory and Owen McDougal), International Conference of Bioinformatics and Computational Biology Proceedings (2011)

Modeling of the collagen α1(XI) amino propeptide (NPP) domain was performed to better understand how...

 

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Clinical Significance of Interleukin (IL)-6 in Cancer Metastasis to Bone: Potential of Anti-IL-6 Therapies (with Ken Tawara and Cheryl L. Jorcyk), Cancer Management and Research (2011)

Metastatic events to the bone occur frequently in numerous cancer types such as breast, prostate,...

 

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Inhibition of Proprotein Convertase Ski-1 Blocks Transcription of Key Extracellular Matrix Genes Regulating Osteoblastic Mineralization (with Jeff P. Gorski, Nichole T. Huffman, Sridar Chittur, Ronald J. Midura, Claudine Black, and Nabil G. Seidah), Journal of Biological Chemistry (2011)

Mineralization, a characteristic phenotypic property of osteoblastic lineage cells, was blocked by AEBSF and dec-RRLL-cmk,...

 

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The Expression Patterns of Minor Fibrillar Collagens During Development in Zebrafish (with Ming Fang, Jason S. Adams, B. Lane Memahhan, and Raquel J. Brown), Gene Expression Patterns (2010)

Minor fibrillar collagens are recognized as the organizers and nucleators during collagen fibrillogenesis but likely...

 

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Differential Expression of Collagen Type V and XI α-1 in Human Ascending Thoracic Aortic Aneurysms, The Annals of Thoracic Surgery (2009)

Background—The molecular mechanisms leading to ascending thoracic aortic aneurysms (ATAAs) remain unknown. We hypothesized that...

 

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Characterization of Collagenous Matrix Assembly in a Chondrocyte Model System (with Sorcha Yingst, Kaci Bloxham, Lisa R. Warner, Raquel J. Brown, Jennifer Cole, Linda Kenoyer, and William B. Knowlton), Journal of Biomedical Materials Research Part A (2009)

Collagen is a major component of the newly synthesized pericellular microenvironment of chondrocytes. Collagen types...

 

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Collagen a1(XI) in Normal and Malignant Breast Tissue (with Karen C. Halsted, Kara B. Bowen, Laura Bond, Sarah E. Lumen, Cheryl L. Jorcyk, William E. Fyffe, and Joseph D. Kronz), Modern Pathology (2008)

Little is known about collagen XI expression in normal and malignant breast tissue. Tissue microarrays,...

 

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Deamidation Destabilizes and Triggers Aggregation of a Lens Protein, βA3-crystallin (with Takumi Takata, Borries Demeler, and Kirsten J. Lampi), Protein Science (2008)

Protein aggregation is a hallmark of several neurodegenerative diseases and also of cataracts. The major...

 

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Immuno-SEM Characterization of Developing Bovine Cartilage (with Michelle Gerritsen, Megan Frary, Jonathan Henderson, and Janet M. Hampikian), Materials Science and Engineering C (2008)

Collagen is a vital material in the tissues of living organisms. Found almost everywhere in...

 

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Immunohistochemical Localization of Collagen Type XI α1 and α2 Chains in Human Colon Tissue (with Karen B. Bowen, Aaron P. Reimers, Sarah Luman, Joseph D. Kronz, and William E. Fyffe), Journal of Histochemistry & Cytochemistry (2008)

In previous studies, collagen XI mRNA has been detected in colon cancer, but its...

 

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Collagen 11a1 is Indirectly Activated by Lymphocyte Enhancer-binding Factor 1 (Lef1) and Negatively Regulates Osteoblast Maturation (with Rachel A. Kahler, Sorcha M.C. Yingst, Luke H. Hoeppner, Eric D. Jensen, David Krawczak, and Jennifer J. Westendorf), Matrix Biology (2008)

Alpha 1 (XI) collagen (Col11a1) is essential for normal skeletal development. Mutations in Col11a1 cause...

 

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Calpain-Cleavage of α-Synuclein: Connecting Proteolytic Processing to Disease-Linked Aggregation (with Brian M. Dufty, Lisa R. Warner, Kristen M. Leenhouts, and Troy T. Rohn), The American Journal of Pathology (2007)

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are both characterized pathologically by...

 

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Suppression of MeCP2β Expression Inhibits Neurite Extension in PC12 Cells (with Sorcha M. Cusack, Troy T. Rohn, Ryan J. Medeck, Katey M. Irwin, Raquel J. Brown, and Linda M. Mercer), Experimental Cell Research (2004)

Regulation of gene expression is critical to the proper development of neuronal cells. The methyl-CpG...

 

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Caspase Activation Independent of Cell Death is Required for Proper Cell Dispersal and Correct Morphology in PC12 Cells (with Troy T. Rohn, Sorcha M. Cusack, and Stephen R. Kessinger), Experimental Cell Research (2004)

Caspase activation is indispensable for the proper execution of apoptosis. However, to date, little is...

 

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Interaction between Amino Propeptides of Type XI Procollagen 1 Chains, Journal of Biological Chemistry (2004)

Type XI collagen is a quantitatively minor yet essential constituent of the cartilage extracellular matrix....

 

Presentations

Studies of Type XI Collagen Interaction (with K. Irwin, Phuong Doan, and Martin Schimpf), Fourteenth International Symposium on Field and Flow-Based Separations (2009)
 

Bone Microarchitecture Is Dependent Upon Collagen α1(XI) Expression During Development, 30th Annual Meeting of the American Society for Bone and Mineral Research (2008)

Collagen type XI is an essential component of the collagen fibrils within the developing skeleton....

 

Characterization of Developing Bovine Cartilage Using Immuno-SEM (with Michelle Gerritsen, Janet Hampikian, Megan Frary, and Jonathan Henderson), Materials Science & Technology 2006 Conference and Exhibition (2006)

Collagen is an important material in tissues of living organisms. Found almost everywhere in the...