My scientific research interests and activities are primarily focused on (1)
developing a theoretical understanding of protein-protein and protein-peptide recognition
(2) developing computational methods to predict and explain protein-protein and
protein-peptide interactions and (3) applying computational methods to identify and
optimize peptide-based and peptide-derived drug leads. 

Additionally, I am interested in exploring and understanding the relationship between
modern empirical science and the philosophy of Aristotle and St. Thomas Aquinas. 

Professor Audie was awarded tenure by the Board of Trustees in May 2013. 

B.S. Bioengineering, Hofstra University (1995) M.S. Biomedical Engineering, University of
Connecticut (2001) Ph.D. Biophysics, SUNY Stony Brook (2006) 



Rational, Computer-Enabled Peptide Drug Design: Principles, Methods, Applications and Future Directions (with David J. Diller, Jon Swanson, and Alexander S. Bayden), Chemistry Faculty Publications (2015)

Peptides provide promising templates for developing drugs to occupy a middle space between small molecules...



A Combined Cheminformatic and Bioinformatic Approach to Address the Proteolytic Stability Challenge in Peptide-Based Drug Discovery (with Alexander S. Bayden, Edwin F. Gomez, Dhruva K. Chakravorty, and David J. Diller), Chemistry Faculty Publications (2015)

We have created models to predict cleavage sites for several human proteases including: caspase-1, caspase-3,...



Advances in the Prediction of Protein-Peptide Binding Affinities: Implications for Peptide-Based Drug Discovery (with Jon Swanson), Chemistry Faculty Publications (2013)

Peptides hold great promise as novel medicinal and biologic agents, and computational methods can help...



Recent Work in the Development and Application of Protein–Peptide Docking (with Jon Swanson), Chemistry Faculty Publications (2012)

Interest in the development of novel peptide-based drugs is growing. There is, thus, a pressing...



The Synergistic Use of Computation, Chemistry and Biology to Discover Novel Peptide-Based Drugs: The Time is Right (with C. Boyd), Chemistry Faculty Publications (2010)

The case for peptide-based drugs is compelling. Due to their chemical, physical and conformational diversity,...