The authors provided an empirical overview of the African regional and national socioeconomic influences on safety management and the leading causes of non-natural fatalities and injuries: Motor vehicle accidents and work accidents in both the formal and informal sectors. The authors point to three different theoretical approaches to African safety management that address the fact that the rate of motor vehicle deaths, for instance, was about 18 times higher than in the U.S. Recommendations for improving African safety management were also provided.