This article suggests differential acceptance and approval of genetic modification involving plant or animal genes. The results can contribute to our understanding of GM food acceptance and be used to derive marketing strategies and in policy formulation. Similar to previous studies, this article suggests that demographic, socio-economic, consumer value attributes, and trust in key stakeholders help drive acceptance of genetic modification. In general, the public is more approving of plant-based GM than animal-based GM. Furthermore, the results of this survey suggest that a better understanding of biotechnology, trust in the GM regulatory framework, and biotechnology corporations’ motives are critical for the acceptance of genetic modification. A general outreach program to educate and inform consumers about biotechnology will not help the public make informed decisions about the desirability of this technology.