Enhanced Antiscrapie Effect Using Combination Drug Treatment
Originally published by the American Society for Microbiology. Publisher's PDF and HTML fulltext available through remote link.
Combination treatment with pentosan polysulfate and Fe(III)meso-tetra(4-sulfonatophenyl)porphine in mice beginning 14 or 28 days after scrapie inoculation significantly increased survival times. This increase may be synergistic, implying that the compounds act cooperatively in vivo. Combination therapy may therefore be more effective for treatment of transmissible spongiform encephalopathies and other protein-misfolding diseases.
Kocisko, D.A., B. Caughey, J.D. Morrey, and R.E. Race 2006. Enhanced antiscrapie effect using combination drug treatment. Antimicrobial Agents and Chemotherapy. 50: 3447-3449.