A Porphyrin Increases Survival Time of Mice after Intracerebral Prion Infection
Originally published by the American Society for Microbiology. Publisher's PDF and HTML fulltext available through remote link.
Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.
Kocisko, D.A., W. S. Caughey, R.E. Race, G. Roper, B. Caughey, and J.D. Morrey 2006. A porphyrin increases survival time of mice after intracerebral prion infection. Antimicrobial Agents and Chemotherapy 50: 759-61.