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Selected Works of John D. Morrey
Article
A Porphyrin Increases Survival Time of Mice after Intracerebral Prion Infection
Antimicrobial Agents and Chemotherapy (2006)
  • D. A. Kocisko
  • W. S. Caughey
  • R. E. Race
  • G. Roper
  • B. Caughey
  • John D. Morrey, Utah State University
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Abstract
Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.
Keywords
  • porphyrin,
  • survival,
  • mice,
  • intracerebral,
  • prion infection
Disciplines
Publication Date
January 1, 2006
Publisher Statement
Originally published by the American Society for Microbiology. Publisher's PDF and HTML fulltext available through remote link.
Citation Information
Kocisko, D.A., W. S. Caughey, R.E. Race, G. Roper, B. Caughey, and J.D. Morrey 2006. A porphyrin increases survival time of mice after intracerebral prion infection. Antimicrobial Agents and Chemotherapy 50: 759-61.