A comparison of failure rates and grade distribution was conducted between four learning disciplines utilized by Embry-Riddle Aeronautical University-Worldwide: Eagle Vision Classroom (synchronous classroom to classroom), Eagle Vision Home (synchronous home to home), Online and traditional classroom learning environments. Researchers examined 20,677 Embry-Riddle end-of-course student grades from the 2012-2013 academic year. Significant relationships between failing grades and learning environment (modes) were noted in courses from the English, Economics and Mathematics disciplines. Online courses experienced more failures relative to other modes of instruction in Humanities, Mathematics and Economics courses. The traditional classroom-learning mode had fewer failures relative to other modes in English, Humanities and Mathematics courses. Grade distribution was significantly different among some of the learning modes in disciplines studied. Due to the continued technological advancements in course delivery, recommendations include continued research on the relationship of student performance and learning mode. Researchers should also conduct quantitative and qualitative research on faculty and student perceptions regarding learning mode preferences.