Two groups of adolescents (N = 114), 61 identified-gifted adolescents (M = 22, F = 39) and 51 vocational school adolescents (M = 27, F = 26), were compared on the Overexcitability Questionnaire. Each of the five Overexcitability (OE) scores—Psychomotor, Sensual, Imaginational, Intellectual, and Emotional—was subjected to a two-way ANOVA by classification and gender. Any statistically significant interaction effect was further analyzed by testing the group means with six two-group comparison tests. The analyses produced the following results: (a) Differences among the Psychomotor, Sensual, and Emotional OE means were not statistically significant, and (b) the Imaginational and Intellectual OE means of the gifted male students were significantly higher than the means of the vocational female students, vocational male students, and gifted female students. The effect sizes were classified as large. A qualitative textual analysis was also conducted. The results were compared with another study of the same gifted population that used the Overexcitability Questionnaire-II.