mRNA expression of canine ATP10C, a P4-type ATPase, is positively associated with body condition score

S Roshwalb
S Gorman
Joe Bartges DVM, PhD, DACVIM, DACVN, University of Tennessee - Knoxville
S Agarwal
Carla Sommardahl, University of Tennessee - Knoxville
Agricola Odoi, University of Tennessee - Knoxville
Madhu S. Dhar, University of Tennessee - Knoxville

Abstract

Mouse and human Atp10c genes are strong candidates for changes in bodyweight and glucose homeostasis. Using comparative genomic analysis, a novel canine P4-type ATPase, ATP10C, was identified. Expression of ATP10C was compared between sex-matched lean (body condition score, BCS<8; n=7) and obese (BCS⩾8, n=8) client-owned dogs of comparable ages. Canine ATP10C is highly expressed in visceral and subcutaneous fat at approximately 3-fold levels compared to the omental adipose depot. There was a 5-fold significant increase (P<0.0001) in mRNA expression of ATP10C in dogs with a BCS⩾8.