Articles

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Neuropsychiatric Symptoms in Dementia Patients With and Without a History of Traumatic Brain Injury (with Vani Rao, Paul Rosenberg, Quincy Samus Miles, Deepa Patadia, Kate Treiber, Melaine Bertrand, Maria Norton, Martin Steinberg, and Constantine Lyketsos), Journal of Neuropsychiatry and Clinical Neurosciences (2010)

The authors aim to determine if a history of traumatic brain injury (TBI) assessed before...

 

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A Brief Metacognition Questionnaire for the Elderly: Comparison with Cognitive Performance and Informant Ratings, The Cache County Study (with Trevor Buckley, Marla C. Norton, M. Scott Deberard, and Kathleen A. Welsh-Bohmer), International Journal of Geriatric Psychiatry (2009)

Objective To examine the utility of a brief, metacognition questionnaire by examining its association with...

 

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Caregiver-Recipient Closeness and Symptom Progression in Alzheimer's Disease: The Cache County Dementia Progression Study (with Maria C. Norton, Kathleen W. Piercy, Peter V. Rabins, Robert C. Green, John C. Breitner, Truis Ostbye, Christopher Corcoran, Kathleen A. Welsh-Bohmer, and Constantine G. Lyketsos), Journal of Gerontology, Series B (2009)

Applying Rusbult's investment model of dyadic relationships, we examined the effect of caregiver–care recipient relationship...

 

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Early Parental Death and Late-Life Dementia Risk - Findings from the Cache County Study (with Maria C. Norton, Truls Ostbye, Ken R. Smith, and Ronald G. Munger), Age and Aging (2009)

SIR—Dementia is a major public health problem. Alzheimer's disease (AD) comprises the majority of dementia...

 

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Neuropsychological performance in advanced age: Influences of demographic factors and Apolipoprotein E: Findings from the Cache County Memory Study (with Kathleen A. Welsh-Bohmer, Truls Ostbye, Linda Sanders, Car; F. Pieper, Kathleen M. Hayden, and Maria C. Norton), The Clinical Neuropsychologist (2009)

The Cache County Study of Memory in Aging (CCMS) is an epidemiological study of Alzheimer's...

 

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Church Attendance and New Episodes of Major Depression in a Community Study of Older Adults: The Cache County Study (with Maria C. Norton, Archana Singh, Ingmar Skoog, Christopher Corcoran, Peter P. Zandi, John C. S. Breitner, Kathleen A. Welsh-Bohmer, and David C. Steffens), Journals of Gerontology: Series B (2008)

We examined the relation between church attendance, membership in the Church of Jesus Christ of...

 

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Point and Five-Year Period Prevalence of Neuropsychiatric Symptoms in Dementia: The Cache County Study (with Martin Steinberg, Hulbo Shao, Peter Zandi, Constantine G. Lyketsos, Kathleen A. Welsh-Bohmer, Maria C. Norton, John C. S. Breitner, and David C. Steffens), International Journal of Geriatric Psychiatry (2008)

Background: Neuropsychiatric symptoms are nearly universal in dementia, yet little is known about their longitudinal...

 

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Regional Atrophy of the Corpus Callosum in Dementia (with Bradley J. Hallam, Warren S. Brown, Chris Ross, J. Galen Buckwalter, Erin D. Bigler, Maria C. Norton, Kathleen A. Welsh-Bohmer, and John C. S. Breitner), Journal of the International Neuropsychological Society (2008)

The regional distribution of degeneration of the corpus callosum (CC) in dementia is not yet...

 

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Autopsy-confirmed Alzheimer's disease versus clinically-diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging: A comparison of quantitative MRI and Neuropsychological Findings (with Michael A. Fearing, Erin D. Bigler, Maria Norton, Christine Hulette, Carol Leslie, and Kathleen Welsh-Bohmer), Journal of Clinical and Experimental Neuropsychology (2007)

Atrophy of specific, regional, and generalized brain structures occurs as a result of the Alzheimer's...

 

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Epidemiology of Apathy in Older Adults - The Cache County Study (with Chiadi U. Onyike, Jeanne-Marie E. Sheppard, Maria C. Norton, Robert C. Green, Martin Steinberg, Kathleen A. Welsh-Bohmer, John C. Breitner, and Constantine G. Lyketsos), American Journal of Geriatric Psychiatry (2007)

Objectives: The objectives of this study are to describe the distribution of apathy in community-based...

 

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A Population-Based Study of the Association between Coronary Artery Bypass Graft Surgery (CABG) and Cognitive Decline: the Cache County Study (with Constantine G. Lyketsos, Leslie Toone, Christopher Corcoran, Maria Norton, Peter Zandi, Ron Munger, John C. S. Breitner, and Kathleen Welsh-Bohmer), International Journal of Geriatric Psychiatry (2006)

Background: The relationship between coronary artery bypass graft (CABG) surgery and cognitive decline remains uncertain,...

 

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Anti-Hypertensive Medication Use and Incident Alzheimer's Disease. The Cache County Study (with Ara S. Khachaturian, Peter P. Zandi, Constantine G. Lyketsos, Kathleen M. Hayden, Ingmar Skoog, Maria C. Norton, Lawrence S. Mayer, Kathleen A. Welsh-Bohmer, and John C. S. Breitner), Archives of Neurology (2006)

Background: Recent reports suggest that antihypertensive (AH) medications may reduce the risk of dementing illnesses....

 

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Gender Differences in the Association between Religious Involvement and Depression:  The Cache County (Utah) Study (with Maria C. Norton, Ingmar Skoog, Lynn M. Franklin, Christopher Corcoran, Peter P. Zandi, John C. S. Breitner, Kathleen A. Welsh-Bohmer, and David C. Steffens), Journals of Gerontology: Series B (2006)

We examined the relation between religious involvement, membership in the Church of Jesus Christ of...

 

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Modifying Dementia Risk and Trajectories of Cognitive Decline in Aging: The Cache County Memory Study (with Kathleen A. Welsh-Bohmer, John C. S. Breitner, Kathleen M. Hayden, Constantine Lyketsos, Peter P. Zandi, Maria C. Norton, and Ron Munger), Alzheimer's & Dementia (2006)

The Cache County Study of Memory, Health, and Aging, more commonly referred to as the...

 

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Risk Factors for Neuropsychiatric Symptoms in Dementia: The Cache County Study (with M. Steinberg, C. Corcoran, C. Huber, K. Welsh-Bohmer, M. C. Norton, P. Zandi, J.C. S. Breitner, D. C. Steffens, and C. G. Lykestsos), International Journal of Geriatric Psychiatry (2006)

Objective: To investigate the probability of individual neuropsychiatric symptoms in dementia patients as a function...

 

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Ten Dimensions of Health and Their Relationships with Overall Self-Reported Health and Survival in a Predominately Religiously Active Elderly Population: The Cache County Memory Study (with Truls Østbye, Katrina M. Krause, Maria C. Norton, Linda Saunders, Kathleen Hayden, Carl Pieper, and Kathleen A. Welsh-Bohmer), Journal of the American Geriatrics Society (2006)

OBJECTIVES: To document the extent of healthy aging along 10 different dimensions in a population...

 

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Apolipoprotein E Genotype and Mortality: Findings From The Cache County Study (with Kathleen M. Hayden, Peter P. Zandi, Constantine G. Lyketsos, Maria C. Norton, Ara S. Khachaturian, Carla F. Pieper, Kathleen A. Welsh-Bohmer, and John C. S. Breitner), Journal of the American Geriatrics Society (2005)

Objectives: To evaluate the association between apolipoprotein E (apo E) ɛ4 and mortality, the population...

 

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Do Statins Reduce Risk of Incident Dementia and Alzheimer's Disease? The Cache County Study (with Peter P. Zandi, D. Larry Sparks, Ara S. Khachaturian, Maria C. Norton, Martin Steinberg, Kathleen A. Welsh-Bohmer, and John C. S. Breitner), Archives of General Psychiatry (2005)

Background: Prior reports suggest reduced occurrence of dementia and Alzheimer disease (AD) in statin users,...

 

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Identification of VaD and AD Prodromes: The Cache County Study (with K. M. Hayden, L. H. Warren, C. F. Pieper, T. Østbye, M. Norton, J.C. S. Breitner, and K. A. Welsh-Bohmer), Alzheimer's and Dementia: The Journal of the Alzheimer's Association (2005)

Background: It is unclear whether vascular dementia (VaD) has a cognitive prodrome, akin to the...

 

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Cerebral Volume Loss, Cognitive Deficit and Neuropsychological Performance: Comparative Measures of Brain Atrophy - I. Dementia (with Erin D. Bigler, E. Shannon Neeley, Michael J. Miller, David F. Tate, Sara A. Rice, Howard Cleavinger, Lara Wolfson, and Kathleen Welsh-Bohmer), Journal of the International Neuropsychological Society (2004)

There are several magnetic resonance (MR) imaging methods to measure brain volume and cerebral atrophy;...

 

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Reduced risk of Alzheimer's Disease in Users of Antioxidant Vitamin Supplements: The Cache County Study (with Peter P. Zandi, James C. Anthony, Ara S. Khachaturian, Stephanie V. Stone, Deborah Gustafson, Maria C. Norton, and John C. S. Breitner), Archives of Neurology (2004)

Background: Antioxidants may protect the aging brain against oxidative damage associated with pathological changes of...

 

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The Persistence of Neuropsychiatric Symptoms in Dementia: The Cache County Study (with Martin Steinberg, Christopher Corcoran, David C. Steffens, Maria C. Norton, Constantine G. Lyketsos, and John C. S. Breitner), International Journal of Geriatric Psychiatry (2004)

Objective: To estimate the 18-month persistence of neuropsychiatric symptoms in dementia in a population-based sample,...

 

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The Incidence of Mental and Behavioral Disturbances in Dementia: The Cache County Study (with Martin Steinberg, Jeannie-Marie E. Sheppard, Maria C. Norton, David C. Steffens, John C. S. Breitner, and Constantine G.. Lyketsos), Journal of Neuropsychiatry and Clinical Neurosciences (2003)

A population-based prevalence sample of 355 residents of Cache County, Utah, who were diagnosed with...

 

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An Adaptation of the Modified Mini-Mental State Examination: Analysis of Demographic Influences and Normative Data. The Cache County Study (with Kathleen A. Welsh-Bohmer, Brenda L. Plassman, Maria C. Norton, Bonita W. Wyse, and John C. S. Breitner), Neuropsychiatry, Neuropsychology & Behavioral Neurology (2002)

Objectives: To present a new version of the Modified Mini-Mental State Examination (3MS-R), provide normative...

 

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Dementia, Asymmetry of Temporal Lobe Structures, and Apolipoprotein E Genotype: Relationships to Cerebral Atrophy and Neuropsychological Impairment (with Erin D. Bigler, David F. Tate, Michael J. Miller, Sara A. Rice, Cory D. Hessel, Heath D. Earl, Brenda Plassman, and Kathleen A. Welsh-Bohmer), Journal of the International Neuropsychological Society (2002)

We examined asymmetry of hippocampal volume as well as other temporal lobe structures (temporal lobe,...

 

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Histamine Receptor Blockade in the Treatment of Alzheimer's Disease: A Randomized, Double-Blind Placebo-Controlled Trial of Nizatidine (with Michelle C. Carlson, Maria C. Norton, Kathleen A. Welsh-Bohmer, Barbara K. Martin, J. Greene, and John C. S. Breitner), Alzheimer Disease and Associated Disorders (2002)

Objectives: To evaluate the efficacy of nizatidine, a histamine H2-blocking drug, in delaying the progression...

 

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Hormone Replacement Therapy and Reduced Cognitive Decline in Older Women: The Cache County Study (with M. C. Carlson, P. A. Zandi, B. L. Plassman, K. A. Welsh-Bohmer, D. C. Steffens, L. Bastian, K. M. Mehta, and J.C. S. Breitner), Neurology (2001)

Objective: To examine the association between postmenopausal hormone replacement therapy (HRT) and the trajectory of...

 

Need for assistance in daily living activities and caregiver stress: Results from a community survey of over 5,000 individuals in Cache County, Utah (with M. C. Norton and T. Calvert), Intermountain Aging Review (2001)
 

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Neuropsychiatric Disturbance in Alzheimer's Disease Clusters into Three Groups: The Cache County Study (with Constantine G. Lyketsos, Jeanne-Marie E. Sheppard, Martin Steinberg, Maria C. Norton, David C. Steffens, and John C. S. Breitner), International Journal of Geriatric Psychiatry (2001)

Objective: We investigated the frequency and inter-relationship of neuropsychiatric disturbances in a population sample of...

 

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Dementia diagnoses from clinical and neuropsychological data compared: The Cache County Study (with K. A. Welsh-Bohmer, I. Skoog, N. West, M. C. Norton, B. W. Wyse, R. Nickles, and J.C. S. Breitner), Neurology (2000)

OBJECTIVE: To validate a neuropsychological algorithm for dementia diagnosis. METHODS: We developed a neuropsychological algorithm...

 

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Mental and Behavioral Disturbances in Dementia: Findings from the Cache County Study on Memory in Aging (with Constantine G. Lyketsos, Martin Steinberg, Maria C. Norton, David C. Steffens, and John C. S. Breitner), American Journal of Psychiatry (2000)

OBJECTIVE: The authors report findings from a study of 5,092 community residents who constituted 90%...

 

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Enhanced Cognitive Performance with Estrogen Use in Non-Demented Community-Dwelling Older Women (with D. C. Steffens, M. C. Norton, B. L. Plassman, B. W. Wyse, K. A. Welsh-Bohmer, J. C. Anthony, and J.C. S. Breitner), Journal of the American Geriatric Society (1999)

OBJECTIVE: To examine the association between history of postmenopausal estrogen use and cognitive function in...

 

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Telephone Adaptation of the Modified Mini-Mental State Exam (3MS): The Cache County Study (with Maria C. Norton, Xitao Fan, Brenda L. Plassman, Kathleen A. Welsh-Bohmer, Nancy M. S. West, Bonita W. Wyse, and John C. S. Breitner), Neuropsychiatry, Neuropsychology and Behavioral Neurology (1999)

Objective: To examine the concurrent validity of a newly developed telephone adaptation of the Modified...

 

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Amphetamine effects on striatal neurons: implications for models of dopamine function (with John L. Haracz, Zhongrui Wang, Karen E. Griffith, and George V. Rebec), Neuroscience and Biobehavioral Reviews (1998)

HARACZ, J. L., J. T. TSCHANZ, Z. WANG, K. E. GRIFFITH AND G. V. REBEC....

 

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APOE Genotype Predicts When - not Whether - One is Predisposed to Develop Alzheimer Disease (with Marion R. Meyer, Maria C. Norton, Kathleen A. Welsh-Bohmer, David C. Steffens, Bonita W. Wyse, and John C. S. Breitner), Nature Genetics (1998)

In an elderly population of 4,932 that included 694 subjects aged 85 and older, we...

 

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Effects of Combining Propofol and Alfentanil on Ventilation, Analgesia, Sedation and Emesis in Human Volunteers (with D. J. Paylin, B. Coda, D. D. Shen, Q. Nguyen, R. Schaffer, G. Donaldson, R. C. Jacobsen, and C. R. Chapman), Anesthesiology (1996)

Propofol and alfentanil frequently are administered together for intravenous sedation. This study investigated pharmacokinetic and...

 

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Cortical Lesions Attenuate the Opposing Effects of Amphetamine and Haloperidol on Neostriatal Neurons in Freely Moving Rats (with Karen E. Griffith, John L. Haracz, and George V. Rebec), European Journal of Pharmacology (1994)

Neuronal activity was recorded from the neostriatum of freely moving rats at least 1 week...

 

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Striatal single-unit responses to amphetamine and neuroleptics in freely moving rats (with John L. Haracz, Zhongrui Wang, Ilsun M. White, and George V. Rebec), Neuroscience & Biobehavioral Reviews (1993)

Single-unit recordings from 50 striatal neurons in freely moving rats revealed generally low activity (<3...

 

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Bilateral Cortical Ablations Attenuate Amphetamine-Induced Excitations of Neostriatal Motor-Related Neurons in Freely Moving Rats (with John L. Haracz, Kareb E. Griffith, and George V. Rebec), Neuroscience Letters (1991)

Single-unit recordings from neostriatal neurons showing movement-related excitations were obtained in freely moving, cortically ablated...

 

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Amphetamine-Induced Excitations Predominate in Single Neostriatal Neurons Showing Motor-Related Activity (with John L. Haracz, Jordan Greenberg, and George V. Rebec), Brain Research (1989)

Neostriatal single-unit activity was recorded in freely moving rats. A majority (62%) of the 24...

 

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Atypical Antipsychotic Drugs Block Selective Components of Amphetamine-Induced Stereotypy (with George V. Rebec), Pharmacology, Biochemistry & Behavior (1988)

Individual items of behavior produced by 1.0 or 5.0 mg/kg d-amphetamine were monitored in rats...

 

Contributions to Books

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Alzheimer's Disease: Risk Factors and Preventive Strategies (with J.C. S. Breitner), Principles and Practice of Geriatric Psychiatry (2010)

The renowned Principles and Practice of Geriatric Psychiatry, now in its third edition, addresses the...

 

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Responses of Motor-and Nonmotor-Related Neostriatal Neurons to Amphetamine and Neuroleptic Drugs (with G. V. Rebec, J. L. Haracz, Z. Wang, and I. W. Wang), Basal Ganglia III (1991)