Areas of interest: microbial diversity and cultivation, bacterial cell-to- cell
communication, biology of the phototrophic bacterium Rhodopseudomonas palustris, hydrogen
gas producing phototrophic bacteria. 

I am broadly interested in the study of the metabolisms and physiologies of environmental
bacteria, and in the culturing of novel bacteria from the environment to gain insight
into the vast microbial diversity that exists on our planet. We live in a microbial world
where microorganisms thrive in nearly all habitats imaginable on earth and make a living
from even the strangest favorable chemical reactions. Microbes are expert biochemists:
they carry out a myriad of chemical transformations, and many of these processes are
useful as solutions for environmental challenges from bioenergy to waste bioremediation.



Production of Hydrogen Gas from Light and the Inorganic Electron Donor Thiosulfate by Rhodopseudomonas palustris, Applied and Environmental Microbiology (2010)

A challenge for photobiological production of hydrogen gas (H2) as a potential biofuel is to...



A New Class of Homoserine Lactone Quorum-Sensing Signals (with Amy L. Schaefer, E P. Greenberg, Colin M. Oliver, Yasuhiro Oda, Gili Bittan-Banin, Caroline M. Peres, Silke Schmidt, Katarina Juhaszova, Janice R. Sufrin, and Caroline S. Harwood), Nature (2008)

Quorum sensing is a term used to describe cell-to-cell communication that allows cell-density-dependent gene expression....



Method of Identifying Agents That Inhibit Quorum-Sensing Activity of Gamma-Proteobacteria (with Jared R. Leadbetter), U.S. Patent No. 7,335,352 (2008)

Screening assays that allow for the identification of agents that increase acyl homoserine lactone (AHL)...



Acyl‐HSL Signal Decay: Intrinsic to Bacterial Cell–Cell Communications (with Ya-Juan Wang and Jared Renton Leadbetter), Advances in Applied Microbiology (2007)

The structure of the signaling molecule of Vibrio fischeri, N-3-(oxohexanoyl) homoserine lactone (3OC6HSL), was determined...



Identification of QuiP, the Product of Gene PA1032, as the Second Acyl-Homoserine Lactone Acylase of Pseudomonas aeruginosa PAO1 (with Ashley Petersen, Marvin Whiteley, and Jared R. Leadbetter), Applied and Environmental Microbiology (2006)

The relevance of the acyl homoserine lactone (acyl-HSL) quorum signals N-3-oxododecanoyl-homoserine lactone (3OC12HSL) and N-butanoyl-homoserine...