Dr. Jean A. Frazier, M.D., is the Robert M. and Shirley S. Siff Chair in Autism and
Professor of Psychiatry and Pediatrics at the University of Massachusetts Medical School.
As Co-Director of the Child and Adolescent Neurodevelopment Initiative (CANDI), Dr.
Frazier directs a broad research program that addresses a variety of scientific problems
relevant to advancing the understanding, diagnosis and treatment of individuals with
neurodevelopmental disorders such as early onset bipolar disorder (BPD), schizophrenia
and autism. The CANDI team studies all three diagnostic groups since there is often
overlap in the clinical symptoms, genetics, and the neuroimaging findings of these
disorders and in the clinical interventions used to treat them. Research with each
diagnostic group of children informs the work done with the other diagnostic groups. For
example, children with autism can have mood dysregulation when asked to shift activities
and a significant subset can suffer from a comorbid bipolar disorder or depressive
disorder. Children with schizophrenia can also look like they have bipolar disorder with
psychotic features and figuring out the diagnostic boundaries can be challenging. By
studying all three groups of children, Dr. Frazier hopes to find biomarkers that might be
specific to each diagnosis. In addition, she hopes to find biomarkers that may be less
specific to diagnosis but more pertinent to disorders of neurodevelopment in general. The
overarching goal is for Dr. Frazier's research efforts to lead to improved care of
children and families affected by these disorders. 

CANDI is involved in a variety of research pursuits including genetic studies,
intervention studies and neuroimaging efforts. Dr. Frazier collaborates with a number of
investigators both locally and nationally in order to tackle difficult questions. The
neuroimaging studies use technologies such as magnetic resonance imaging (MRI) to
investigate the development of brain structure and function. Using these techniques Dr.
Frazier's team hopes to characterize normal development and advance the
understanding of issues surrounding mental illness and atypical development and their
interventions. 

Articles

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Frequency and pattern of childhood symptom onset reported by first episode schizophrenia and clinical high risk youth (with Kristen A. Woodberry, Rachael A. Serur, Sean B. Hallinan, Raquelle I. Mesholam-Gately, Anthony J. Giuliano, Joanne D. Wojcik, Matcheri S. Keshavan, Jill M. Goldstein, Martha E. Shenton, Robert W. McCarley, and Larry J. Seidman), Schizophrenia research (2014)
 

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Aripiprazole Decreases Irritability in 12 out of 14 Youth with Autism Spectrum Disorders (with Ann E. Maloney and Eric O. Mick), Journal of child and adolescent psychopharmacology (2014)
 

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Childhood maltreatment, emotional dysregulation, and psychiatric comorbidities (with Yael Dvir, Julian D. Ford, and Michael Hill), Harvard review of psychiatry (2014)
 

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Structure-centered portal for child psychiatry research (with Pallavi Rane, Christian Haselgrove, Steven M. Hodge, and David N. Kennedy), Frontiers in neuroinformatics (2014)
 

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Introduction (with Christopher J. McDougle), Harvard review of psychiatry (2014)
 

Contributions to Books

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Aggression (with Bruce Meltzer and Martha Castro), Pediatric Psychopharmacology: Principles and Practice (2010)
 

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Atypical Antipsychotics in the Treatment of Early Onset Bipolar Disorder (with Hallie Bregman and Joseph A. Jackson), Treating Child and Adolescent Bipolar Disorder (2008)
 

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Bipolar Disorder in Children with Pervasive Developmental Disorders (with Sandra DeJong), Bipolar Disorder in Childhood and Early Adolescence (2005)
 

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Autism, Asperger’s and Schizophrenia (with Sufen Chiu), Saunders manual of pediatric practice (2002)
 

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Mental Retardation (with Sufen Chiu), Saunders manual of pediatric practice (2002)
 

Presentations and Posters

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The Role of Glutamate and GABA in Autism Spectrum Disorders: Pilot Results from a Proton Magnetic Resonance Spectroscopy Study (with David E. Cochran, Elif M. Sikoglu, Daniel Fallon, David N. Kennedy, Steven M. Hodge, Ann Foley, Lauren J. Yakutis, and Constance M. Moore), UMass Center for Clinical and Translational Science Research Retreat (2013)
 

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CANDI Store: An Infrastructure for Neuroimage Storage and Processing (with Christian Haselgrove, Steven M. Hodge, Pallavi Rane, and David N. Kennedy), Clinical and Translational Science Research Retreat (2012)
 

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Mood Disorders and Trauma: What are the Associations? (with Yael Dvir, Michael Hill, and Steven M. Hodge), Clinical and Translational Science Research Retreat (2012)
 

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Mood Disorders and Trauma – What are the Associations? (with Yael Dvir and Michael Hill), American Academy of Child & Adolescent Psychiatry Annual Meeting (2011)
 

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Mood Disorders and Trauma – What are the Associations? Future Directions (with Yael Dvir and Michael Hill), UMass Department of Psychiatry Research Day (2010)