Multidisciplinary collaboration provides opportunities for growth in any simulation program. Simulation coordinators pursuing excellence may find unlikely partners among health care and non–health care professionals. Non-nursing collaborations can offer students, faculty, and simulation coordinators fresh views about simulation in an interdisciplinary climate. Examples of cooperative work with instructors and researchers in radiology, sports medicine, and criminal justice studies are described. Sports medicine students participated in scenarios involving a school-aged child with a spontaneous pneumothorax, a coach who was having a stroke, a pregnant yoga instructor experiencing an asthma attack, and a football player who had been momentarily unconscious after a tackle. Nursing students were asked to participate in criminal justice scenarios because of their understanding of simulation principles.