Dr. Melling’s primary research interest resides in studying the role of exercise in
Type 1 Diabetics. Through functional and histological evidence it is apparent that
neurological information to the pancreas is disturbed in Type 1 diabetic patients,
ultimately leading to inadequate metabolic regulation. Studies are being conducted in his
laboratory to better understand the role of the nervous system in the regulation of the
pancreatic secretion. By ascertaining these regulatory mechanisms, we will better be able
to examine intervening methods both pharmacological and physiological (i.e. exercise), to
better balance the nervous control of pancreas function in Type I diabetes. 

Heat Shock Proteins

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Myocardial Hsp70 Phosphorylation and PKC-Mediated Cardioprotection following Exercise (with David B. Thorp, Kevin J. Milne, and Earl G. Noble), Cell Stress Chaperones (2009)

Both protein kinase C (PKC) activation and Hsp70 expression have been shown to be key...

 

Heat Shock Proteins and Whole Body Physiology (with Earl G. Nobe and Kevin J. Milne), HSP, Exercise and Skeletal Muscle (2008)
 

Link

Invited Review: Heat Shock Proteins and Exercise: A Primer (with Earl G. Noble and Kevin J. Milne), Applied Physiology, Nutrition, and Metabolism (2008)

Heat shock proteins (HSPs) are, in general, prosurvival molecules within the cellular environment, and the...

 

Link

Exercise-Mediated Regulation of Hsp70 Gene Expression Following Exercise Training (with David B. Thorp, Kevin J. Milne, Matthew P. Krause, and Earl G. Noble), American Journal of Physiology - Heart and Circulatory Physiology (2007)

An issue central to understanding the biological benefits associated with regular exercise training is to...

 

Link

PKA-Mediated ERK1/2 Inactivation and Hsp70 Gene Expression Following Exercise (with Matthew P. Krause and Earl G. Noble), Journal of Molecular and Cellular Cardiology (2006)

Exercise induces the expression of the cardioprotective protein, Hsp70, through the activation of its transcription...

 

Diabetes

Link

Diabetic Rates and Mice are Resistent to Porcine and Human Insulin: Flawed Experimental Models for testing Islet Xenograft (with A. R. Pepper, C. Gall, D. Mazzuca, and D. J. White), Xenotransplantation (2009)

BACKGROUND: Islet transplantation is potentially a promising therapy for the restoration of carbohydrate control to...

 

OpenURL

Imaging of Transplanted Pancreatic Islets in Vivo (with P. Joo Ho Tai, C. Foster, C. Hasil, and D. J. White), Cell Transplant (2008)
 

OpenURL

Imaging Islets Labeled wth Magnetic Nanoparticules at 1.5 Tesla (with J.H. Tai, Paula Foster, Alma Rosales, Biao Feng, Craig Ha, Violetta Martinez, Soha Ramadan, Jonatan Snir, Savita Dhanvantari, Brian Rutt, and David J.G. White), Diabetes (2006)

We have developed a magnetic resonance imaging (MRI) technique for imaging Feridex (superparamagnetic iron oxide...