Canine IgE 2c myeloma with Mott and flame cells.

D. H. Altman
D. J. Meyer
James P. Thompson, University of Florida
E. A. Bailey

Abstract

A general description of the clinical and histopathological features (flame cells with an affinity for eosin, and Mott cells containing secretory deposits of immunoglobulins - Russell's bodies) of plasma cell myelomas is given. A case report is presented of a 15-year-old poodle with this condition. Of particular interest was the appearance of most plasma cells in bone marrow impression smears as Mott or flame cells, and the finding of an alteration in the synthesis of normal immunoglobulins. Serum immunoglobulin measurements showed decreased concentrations of IgA, IgM and IgG 2ab in the presence of an IgG 2c monoclonal gammopathy.