Pathology of experimental infection with Brugia malayi in ferrets: comparison with occult filariasis in man.
Ferrets experimentally infected with Brugia malayi (subperiodic strain) developed eosinophilia at patency and usually became amicrofilaremic. Ferrets necropsied within 3 months after becoming amicrofilaremic had granulomas and focal reactions to degenerating microfilariae in their livers, lungs and lymph nodes essentially identical to those of tropical eosinophilia. Four of 7 ferrets that received multiple inoculations of larvae, developed edema of the inoculated paw and leg after becoming amicrofilaremic and 6 of these 7 ferrets had granulomatous lymphangitis and lymphadenitis of inoculated limbs but not the lesions of lung and liver characteristic of occult infection.
R. B. Crandall, James P. Thompson, D. H. Connor, P. B. McGreevy, and C. A. Crandall. "Pathology of experimental infection with Brugia malayi in ferrets: comparison with occult filariasis in man." Acta Tropica 41.4 (1984): 373-381.
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