Odor profiling efforts were directed at applying to high-density livestock operations, some of the lessons learned in resolving past, highly diverse, odor-focused investigations in the consumer product industry. Multidimensional-GC-Olfactometry was utilized in an attempt to define and prioritize the basic building blocks of odor character associated with representative cattle feedyard and swine feeding operations. Although scores of potential odorant volatiles have been previously identified in high-density livestock operations, the odor profile results developed herein suggest that only a very few of these may constitute the preponderance of the odor complaints associated with these environments. This appeared to be especially true for the case of increasing distance from the cattle feedyard facilities; with para-cresol consistently taking on the preeminent odor impact role with ever increasing distance. In contrast, at or near-site odor profiles were shown to be much more complex; with many of the traditional lower tier odorant compounds rising in relative significance. Surprisingly, for the at or near-site odor profiles, trimethylamine was shown to represent a significantly greater individual odor impact relative to hydrogen sulfide, the organic sulfides and volatile fatty acids; the more often cited target odorants.