My research interests are to pursue novel molecules functioning in apoptosis of
malignantly transformed cells and to build translational research as a bridge from basic
research to clinical research and applications for anticancer therapeutics and
prevention. The goal of my basic research is to have a better understanding of the
control of human cancers through exploration of novel signaling pathways for regulating
cellular transformation, quiescence, and apoptosis. The approach of my translational
research is to build preclinical models that reflect the molecular basis of cancer
etiology and progression and for studies of tumor biology and etiology. Through molecular
classification of oncogene- or carcinogen-induced human cancer cells, the biological,
biochemical, genetic, and molecular changes will be utilized as elements to constitute
unique, identifiable characteristics of signatures of precancerous and cancerous cells at
all stages of cancer development. Based on the biological and molecular signatures of
precancerous and cancerous cells, we will be able to determine the stage of cancers and
identify molecular targets for choosing agents that prevent cancer by interfering with
the biological processes underlying cancer development or selectively induce apoptosis of
cancerous cells. Through collaborations we expect to establish research programs with
multi-disciplines to link basic molecular and cellular research to clinical studies that
will benefit our society for anticancer prevention and treatment. 

Articles

OpenURL

Induction of human breast cell carcinogenesis by triclocarban and intervention by curcumin (with S Sood and S Choudhary), Biochemical and Biophysical Research Communications (2013)

More than 85% of breast cancers are sporadic and attributable to long-term exposure to environmental...

 

OpenURL

Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (with Shambhunath Choudhary, Shilpa Sood, and Robert L. Donnell), Carcinogenesis (2012)

More than 85% of breast cancers are sporadic and attributable to long-term exposure to environmental...

 

OpenURL

Reactive oxygen species-mediated therapeutic control of bladder cancer. (with Shambhunath Choudhary), Nature Reviews Urology (2011)

Urinary bladder cancer is the fifth most common cancer in the US and the most...

 

OpenURL

Differential induction of reactive oxygen species through Erk1/2 and Nox-1 by FK228 for selective apoptosis of oncogenic H-Ras-expressing human urinary bladder cancer J82 cells (with Shambhunath Choudhary and K Rathore), Journal of Cancer Research and Clinical Oncology (2011)

PURPOSE: This study sought to reveal mechanisms for differential regulation of reactive oxygen species (ROS)...

 

OpenURL

Green tea catechin extract in intervention of chronic breast cell carcinogenesis induced by environmental carcinogens (with Kusum Rathore), Molecular Carcinogenesis (2011)

Sporadic breast cancers are mainly attributable to long-term exposure to environmental factors, via a multi-year,...