My research interests are to pursue novel molecules functioning in apoptosis of malignantly transformed cells and to build translational research as a bridge from basic research to clinical research and applications for anticancer therapeutics and prevention. The goal of my basic research is to have a better understanding of the control of human cancers through exploration of novel signaling pathways for regulating cellular transformation, quiescence, and apoptosis. The approach of my translational research is to build preclinical models that reflect the molecular basis of cancer etiology and progression and for studies of tumor biology and etiology. Through molecular classification of oncogene- or carcinogen-induced human cancer cells, the biological, biochemical, genetic, and molecular changes will be utilized as elements to constitute unique, identifiable characteristics of signatures of precancerous and cancerous cells at all stages of cancer development. Based on the biological and molecular signatures of precancerous and cancerous cells, we will be able to determine the stage of cancers and identify molecular targets for choosing agents that prevent cancer by interfering with the biological processes underlying cancer development or selectively induce apoptosis of cancerous cells. Through collaborations we expect to establish research programs with multi-disciplines to link basic molecular and cellular research to clinical studies that will benefit our society for anticancer prevention and treatment.
Articles
Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (with Shambhunath Choudhary, Shilpa Sood, and Robert L. Donnell), Carcinogenesis (2012)
More than 85% of breast cancers are sporadic and attributable to long-term exposure to environmental...
Reactive oxygen species-mediated therapeutic control of bladder cancer. (with Shambhunath Choudhary), Nature Reviews Urology (2011)
Urinary bladder cancer is the fifth most common cancer in the US and the most...
Differential induction of reactive oxygen species through Erk1/2 and Nox-1 by FK228 for selective apoptosis of oncogenic H-Ras-expressing human urinary bladder cancer J82 cells (with Shambhunath Choudhary and K Rathore), Journal of Cancer Research and Clinical Oncology (2011)
PURPOSE: This study sought to reveal mechanisms for differential regulation of reactive oxygen species (ROS)...
Green tea catechin extract in intervention of chronic breast cell carcinogenesis induced by environmental carcinogens (with Kusum Rathore), Molecular Carcinogenesis (2011)
Sporadic breast cancers are mainly attributable to long-term exposure to environmental factors, via a multi-year,...
Oncogenic H-Ras, FK228, and exogenous H2O2 cooperatively activated the ERK pathway in selective induction of human urinary bladder cancer J82 cell death (with Shambhunath Choudhary and KKA Wang), Molecular Carcinogenesis (2011)
More than 35% of human urinary bladder cancers involve oncogenic H-Ras activation. The goal of...