Research focuses on the development of novel strategies for the prevention and
treatment of cancer in the lungs and pancreas. Lung cancer and pancreatic cancer are the
leading causes of cancer mortality in the United States and all over the world because
they fail to respond to existing cancer therapeutics and efforts to prevent these cancers
by dietary measures or pharmacological treatments. 

Articles

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Chronic exposure to estrogen and the tobacco carcinogen NNK cooperatively modulate nicotinic receptors in small airway epithelial cells (with Mohammed H. Al-Wadei, Thomas Masi, and Hildegard M. Schuller), Lung Cancer (2010)

Small airway epithelial cell-derived adenocarcinoma is the most common human lung cancer and is particularly...

 

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Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter gamma-aminobutyric acid (with Howard K. Plummer III and Hildegard M. Schuller), Carcinogenesis (2009)

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer mortality in Western countries. We...

 

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Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas (with Hildegard M. Schuller), Journal of Pathology (2009)

Small airway-derived pulmonary adenocarcinoma (PAC) and pancreatic ductal adenocarcinoma (PDAC) are among the most common...

 

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Non-genomic inhibitory signaling of ß-carotene in squamous cell carcinoma of the lungs (with Hildegard M. Schuller), International Journal of Oncology (2009)

Studies have suggested that retinoids prevent lung cancer by interacting with nuclear retinoid receptors. However,...

 

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Prevention of pancreatic cancer by the beta-blocker propranolol (with Mohammed H. Al-Wadei and Hildegard M. Schuller), Anti-Cancer Drugs (2009)

Pancreatic ductal adenocarcinoma (PDAC) is among the leading causes of cancer deaths and is unresponsive...

 

Contributions to Books

Beta-carotene-induced non-genomic signaling and cancer (with Hildegard M. Schuller), Beta Carotene: Dietary Sources, Cancer and Cognition (2010)

β-Carotene is an organic compound - a red-orange pigment abundant in plants and fruits. As...