Articles
Dual Inhibition Of Sodium-Mediated Proton And Calcium Efflux Triggers Non-Apoptotic Cell Death In Malignant Gliomas (with William Harley, Candace Floyd, Tamara Dunn, Xiao-Dong Zhang, Tsung-Yu Chen, Manu Hegde, Michael H. Nantz, Leonardo Leon, K.L. Carraway III, Bruce Lyeth, and Fredric A. Gorin), Brain Research (2010)
Malignant glioma cells maintain an elevated intracellular pH (pHi) within hypoxic–ischemic tumormicroenvironments through persistent activation...
A Facile Synthesis of (tert-alkoxy)amines (with Chris M. Bocian, Michelle R. McCombs, and Michael H. Nantz), Tetrahedron Letters (2005)
Tertiary alcohols react with stoichiometric BF3·Et2O and N-hydroxyphthalimide to yield N-alkoxyphthalimides. Subsequent hydrazinolyses afford the...
Reductive dehydroxy coupling of 2-(hydroxymethyl)indenes to prepare ethano-bridged bis(2-indenyl) ansa-titanocenes (with Justin K. Wyatt, Shawn R. Hitchcock, Marilyn M. Olmstead, and Michael H. Nantz), Journal of Organometallic Chemistry (1999)
New examples of ansa-titanocenes derived from 1,2-bis(2-indenyl)ethane have been prepared. The titanium-mediated reductive coupling of...
An Improved Synthesis Of 2-(Hydroxymethyl)Indene (with William T. McMillen and Michael H. Nantz), Organic Preparations and Procedures International (1996)
Patents
Process for the Preparation of Citalopram Intermediate (with Aslam A. Malik, Joy A. Stringer, DerShing Huang, Antonio Romero, and Olivier Dapremont), United States Patent Number: 6,967,259 B2 (2005)
The present invention provides, inter alia, a novel process for the preparation of Citalopram, a...
Clean, High-yield Preparation Of S,S- and R,S- Amino Acid Isosteres (with Aslam A. Malik, Todd E. Clement, James Robinson III, and Joy A. Stringer), United States Patent Number: 6,867,311 B2 (2005)
The present invention provides compounds and methods that can be used to convert the intermediate...
Preparation of 2S,3S-N-Isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines (with Aslam A. Malik, Joy A. Stringer, Roland P. Carlson, John Leach, Thomas G. Archibald, and Robert G. Miotke), United States Patent Number: 6,852,887 B2 (2005)
The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4phenylbutyl)- p-nitrobenzenesulfonylamide hydrochloride, wherein...
Presentations
Alkoxyamine Polymers: Versatile Materials for Surface Ligation Applications (with Lindsey Hines, Jessica Moore, David Dahl, Belinda Lady, and Johnathan Brantley), 60th Southeastern Regional Meeting Of The American Chemical Society Proceedings: Nashville, Tennessee. (2008)
Immobilization of biomolecules (i.e., proteins, carbohydrates), on polymeric surfaces has been an area of intense...
Cariporide Prodrugs: Targeting Brain Cancer Cells through Sodium-Proton Exchange Inhibition (with Jacob Vervynckt, Johnathan Brantley, Jessica Moore, Mark Graves II, William Harley, and Fredric A. Gorin), 60th Southeastern Regional Meeting Of The American Chemical Society Proceedings: Nashville, Tennessee. (2008)
More than 200,000 people in the United States are diagnosed with a primary or metastatic...
Removal of Benzaldehyde from Methanol Using Alkoxyamine Functionalized Silica Gel (with Dino Sulejmanovic, Carrie Jo Pruitt, Eric Conte, and Shing-Yi Suen), 60th Southeastern Regional Meeting Of The American Chemical Society Proceedings: Nashville, Tennessee. (2008)
Alkoxyamines (RONH2) react readily with aldehydes and ketones to form stable oxime ethers, and, thus...
The Effects of a Networked Data Acquisition System on Student Learning in General Chemistry Laboratories (with Stuart C. Burris, Les L. Pesterfield, Darwin Dahl, and Jacqueline Pope-Tarrence), 60th Southeastern Regional Meeting Of The American Chemical Society Proceedings: Nashville, Tennessee. (2008)
We have recently incorporated a networked data acquisition and analysis system into in our second...
Progress Toward Cariporide Analogs for Sodium-Proton Exchange Inhibition (with Jessica Moore, Mark Graves II, Jacob A. Vervynckt, William Harley, and Fredric Gorin), 235th National Meeting Of The American Chemical Society Proceedings: New Orleans, Louisiana (2008)
The sodium proton exchanger (NHE) is particularly important in maintaining the intracellular pH in human...