This study is designed to investigate the role of Enterprise Resource Planning (ERP) on employee involvement and affect cost reduction of the overall business process. Structural equation models were developed to examine the role of employee involvement, time management, and system operation process in cost reductions. This study focuses on cold chain industry firms. This industry needs effective operation for their fresh products that need to be delivered from the origin to destination on time. The structural equation model was applied to discover the framework that is composed of three mediators. The results found that ERP strategies of firms have a direct effect on employee involvement, the system operation process, and time management, which have an indirect effect of cost reduction.