Parental incarceration has been linked to a wide range of negative intergenerational consequences, including involvement in the criminal justice system. Prior research indicates that those who experience episodes of parental incarceration during childhood are significantly more likely to report contact with the police, arrest, conviction, and incarceration. There remains, however, considerable debate as to whether these relationships are causal or merely correlational. Although many theoretical frameworks offer guidance in understanding these associations (e.g., social learning, strain, labeling), less work has focused on genetic risk factors. Using data from a nationally representative sample of American youth, we conduct a series of analyses to assess whether genetic risk factors, measured by three dopamine polymorphisms (DAT1, DRD2, and DRD4) confound the association between paternal incarceration and child’s arrest and incarceration. Results suggest that genetic risk may confound the relationship between father’s incarceration and child’s arrest but not incarceration. These findings are discussed relative to theoretical development and existing empirical evidence. Directions for future research in this vein are also presented.