Hildegard M. Schuller, D.V.M., Ph.D. is Chief of the Experimental Oncology
Laboratory, Distinguished Professor of Comparative Pathology, College of Veterinary
Medicine, University of Tennessee Knoxville, TN, USA. 

Dr. Schuller earned her professional degrees (D.V.M. and Ph.D. equivalents) at the
College of Veterinary Medicine, Giessen (Germany) and the Medical School Hannover
(Germany. She held positions as Assistant and Associate Professor at the Medical School
Hannover (Germany) followed by appointments at the National Cancer Institute Frederick
Cancer research Center, Frederick, MD and the Division of Cancer treatment, national
Cancer Institute, Bethesda, MD. Dr. Schuller joined the University of Tennessee in 1985. 

Dr. Schuller is a member of various professional societies, including the American
Association for Cancer Research, American Association of Pathology and the Federation of
American Societies for Experimental Biology. Dr. Schuller is member of the Editorial
Academy of the International Journal of Oncology, and member of the Editorial Board of
Anti-Cancer Drugs. She has served on several NIH Study Sections. 

Dr. Schuller’s research focuses on the role of neurotransmission in the development and
progression of lung cancer and pancreatic cancer and the potential targeting of
neurotransmitter receptor pathways for the prevention and therapy of these cancers. Dr.
Schuller is the discoverer of a growth-regulating role of nicotinic acetylcholine
receptors for small cell lung cancer and of beta-adrenergic receptors and GABA-B
receptors for adenocarcinomas of the lungs and pancreas. She was the first to document a
direct interaction of cancer causing tobacco-specific nitrosamines with these
neurotransmitter receptors and their associated growth-regulating signal transduction
pathways. Her pioneering findings have been honored with the Alton Ochsner Award Relating
Smoking and Health by the Alton Ochsner Foundation in 1994 and the Distinguished Service
Award by the Association for Women veterinarians in 1995. Dr. Schuller has published 228
peer-reviewed articles in national and international professional journals. 

Articles

OpenURL

Impact of neuro-psychological factors on smoking-associated lung cancer., Cancers (Basel) (2014)

Smoking has been extensively documented as a risk factor for all histological types of lung...

 

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Chronic nicotine inhibits the therapeutic effects of gemcitabine on pancreatic cancer in vitro and in mouse xenografts (with J. Banerjee and H. A. Al-Wadei), Eur J Cancer (2013)

AIM OF STUDY: Smoking is an established risk factor for pancreatic cancer and nicotine replacement...

 

OpenURL

Gamma-amino butyric acid (GABA) prevents the induction of nicotinic receptor-regulated signaling by chronic ethanol in pancreatic cancer cells and normal duct epithelia (with M. H. Al-Wadei and H. A. Al-Wadei), Cancer Prev Res (Phila) (2013)

Pancreatic cancer has a high mortality rate and alcoholism is a risk factor independent of...

 

OpenURL

Effects of chronic nicotine on the autocrine regulation of pancreatic cancer cells and pancreatic duct epithelial cells by stimulatory and inhibitory neurotransmitters (with M. H. Al-Wadei and H. A. Al-Wadei), Carcinogenesis (2012)

Pancreatic ductal adenocarcinoma (PDAC) has a mortality rate near 100%. Smoking is a documented risk...