Hildegard M. Schuller, D.V.M., Ph.D. is Chief of the Experimental Oncology Laboratory, Distinguished Professor of Comparative Pathology, College of Veterinary Medicine, University of Tennessee Knoxville, TN, USA. Dr. Schuller earned her professional degrees (D.V.M. and Ph.D. equivalents) at the College of Veterinary Medicine, Giessen (Germany) and the Medical School Hannover (Germany. She held positions as Assistant and Associate Professor at the Medical School Hannover (Germany) followed by appointments at the National Cancer Institute Frederick Cancer research Center, Frederick, MD and the Division of Cancer treatment, national Cancer Institute, Bethesda, MD. Dr. Schuller joined the University of Tennessee in 1985. Dr. Schuller is a member of various professional societies, including the American Association for Cancer Research, American Association of Pathology and the Federation of American Societies for Experimental Biology. Dr. Schuller is member of the Editorial Academy of the International Journal of Oncology, and member of the Editorial Board of Anti-Cancer Drugs. She has served on several NIH Study Sections. Dr. Schuller’s research focuses on the role of neurotransmission in the development and progression of lung cancer and pancreatic cancer and the potential targeting of neurotransmitter receptor pathways for the prevention and therapy of these cancers. Dr. Schuller is the discoverer of a growth-regulating role of nicotinic acetylcholine receptors for small cell lung cancer and of beta-adrenergic receptors and GABA-B receptors for adenocarcinomas of the lungs and pancreas. She was the first to document a direct interaction of cancer causing tobacco-specific nitrosamines with these neurotransmitter receptors and their associated growth-regulating signal transduction pathways. Her pioneering findings have been honored with the Alton Ochsner Award Relating Smoking and Health by the Alton Ochsner Foundation in 1994 and the Distinguished Service Award by the Association for Women veterinarians in 1995. Dr. Schuller has published 228 peer-reviewed articles in national and international professional journals.
Articles
Beta-adrenergic signaling in the development and progression of pulmonary and pancreatic adenocarcinoma (with Hussein A.N. Al-Wadei), Current Cancer Therapy Reviews (2011)
Small airway epithelial cells from, which most pulmonary adenocarcinomas (PACs) derive, and pancreatic duct epithelia,...
Regulation of pancreatic cancer by neuro-psychological stress responses: a novel target for intervention (with Hussein A.N. Al-Wadei, Mohammad F. Ullah, and Howard K. Plummer III), Carcinogenesis (2011)
Pancreatic cancer has a poor prognosis and is associated with high levels of psychological stress...
Social stress promotes and γ-aminobutyric acid inhibits tumor growth in mouse models of non small cell lung cancer (with Hussein A.N. Al-Wadei, Howard K. Plummer III, Mohammad F. Ullah, Benjamin Unger, and Joel Brody), Cancer Prevention Research (2011)
Psychological distress is associated with increased lung cancer incidence and mortality. We have shown that...
Neurotransmitter receptors as central regulators of pancreatic cancer (with Hussein A.N. Al-Wadei), Future Oncology (2010)
Pancreatic ductal adenocarcinoma (PDAC) has a near 100% mortality because it is generally detected at...
Chronic exposure to estrogen and the tobacco carcinogen NNK cooperatively modulates nicotinic receptors in small airway epithelial cells (with Hussein Abdulhadi Nasser Al-Wadei, Mohammed H. Al-Wadei, and Thomas Masi), Lung Cancer (2010)
Small airway epithelial cell-derived adenocarcinoma is the most common human lung cancer and is particularly...