Professor Clark's research focuses on the development of fluorescent
nanosensors for in vitro and in vivo analyte detection. Her lab has developed novel
nanosensors, including an Ion-Selective Quantum Dot (ISQD) and a glucose-sensitive
"tattoo." They are currently expanding their range of sensors into other areas,
including redox-active species and small molecules. For every application, the lab is
dedicated to applying their sensors to real problems in biology and medicine. They have
built strong collaborations with investigators at Harvard University, BIDMC, Boston
University, MIT and Tufts Medical Center in order to bring a team approach to these



Sub-wavelength plasmonic readout for direct linear analysis of optically tagged DNA (with Jonathan Varsanik, William Teynor, John LeBlanc, Jeffrey Krogmeier, Tian Yang, and Jonathan Bernstein), Bouvé Faculty Publications (2010)

This work describes the development and fabrication of a novel nanofluidic flow-through sensing chip that...



Second-harmonic imaging microscopy of living cells (with Paul J. Campagnola, William A. Mohler, Aaron Lewis, and Leslie M. Loew), Bouvé Faculty Publications (2001)

Second harmonic generation (SHG) has been developed in our laboratories as a high-resolution nonlinear optical...



Novel optical biosensors using a gold colloid monolayer substrate (with Greg Merritt and Raoul Kopelman), Bouvé Faculty Publications (2000)

A novel optical biosensor matrix has been developed to exploit the native fluorescence of certain...



A comparative study of optical fluorescent nanosensors (PEBBLEs) and fiber optic microsensors for oxygen sensing (with Z. Chen-Esterlit, S. F. Peteu, W. McDonald, and R. Kopelman), Bouvé Faculty Publications (1999)

In this paper we report the use of phase sensitive fluorometry to obtain preliminary results...



Optochemical nanosensors for intracellular chemical measurement (with Raoul Kopelman, Michael T. Miller, Murphy Brasuel, Marion Hoyer, and Martin Philbert), Bouvé Faculty Publications (1998)

The development of a submicron optical fiber "supertip" has provided advantages over previously produced submicron...