Dr. Gyongyi Szabo, M.D., Ph.D., is Professor of Medicine in the Division of
Gastroenterology, Department of Medicine, University of Massachusetts Medical School. Her
current bench research activities include: (1) Immune alterations induced by acute
alcohol consumption; (2) Intracellular signaling pathways in leukocytes mediating altered
cytokine production after acute alcohol use; (3) Immune mechanisms leading to increased
liver injury in HCV plus alcohol; and (4) Immunopathogenesis of liver injury in obese
mice. Clinical research activities include (1) Immune mechanisms of increased liver
injury in HCV plus alcohol (overlap with bench research project #3); (2) Therapeutic
studies in chronic hepatitis C; (3) Therapeutic approaches in non-alcoholic
steatohepatitis (NASH); and (4) Fatty liver disease in morbidly obese patients undergoing
bariatric surgery.

Articles

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Type III Interferons, IL-28 and IL-29, Are Increased in Chronic HCV Infection and Induce Myeloid Dendritic Cell-Mediated FoxP3+ Regulatory T Cells (with Angela Dolganiuc, Karen Kodys, Christopher Marshall, Banishree Saha, Shuye Zhang, and Shashi Bala), PloS one (2012)
 

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IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice (with Jan Petrasek, Shashi Bala, Timea Csak, Dora Lippai, Karen Kodys, Victoria Menashy, Matthew Barrieau, So-Yun Min, and Evelyn A. Kurt-Jones), The Journal of clinical investigation (2012)
 

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Induction of Bcl-3 by acute binge alcohol results in Toll-like receptor 4/LPS tolerance (with Shashi Bala, Alexander Tang, Donna Catalano, Jan Petrasek, Odette Taha, and Karen Kodys), Journal of leukocyte biology (2012)
 

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Inflammasomes in liver diseases (with Timea Csak), Journal of hepatology (2012)
 

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Ethanol facilitates HCV replication via upregulation of GW182 and HSP90 in human hepatoma cells (with Terence N. Bukong, Wei Hou, and Karen Kodys), Hepatology (Baltimore, Md.) (2012)
 

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Contributions to Books

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Toll-like Receptors (with Pranoti Mandrekar), Signaling Pathways in Liver Diseases (2010)
 

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Modulation of Cytokine Production in Human Lymphoid and Myeloid Cells by Alcohol In Vitro (with Pranoti Mandrekar, Bikash K. Verma, and Donna Catalano), Alcohol, Drugs of Abuse and Immune Function (1995)
 

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Monocyte-Mediated Immunodepression after Acute Ethanol Exposure, Alcohol, Drugs of Abuse and Immunomodulation: proceedings of the 2nd International Conference on Alcohol, Drugs of Abuse and Immunomodulation (AIDS) held in Arizona, USA, on 9-13 September 1992 (1993)
 

Posters and Presentations

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Caspase-1-dependent, IL-1ß-mediated alcoholic steatohepatitis is ameliorated by IL-1 receptor antagonist treatment in mice (with Jan Petrasek, Shashi Bala, Dora Lippai, Karen Kodys, Victoria Menashy, Matthew Barrieau, and Evelyn A. Kurt-Jones), Clinical and Translational Science Research Retreat (2012)
 

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CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of HCV-infected cells and induction of IFNα (with Shuye Zhang and Karen Kodys), Clinical and Translational Science Research Retreat (2012)
 

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Increased oxidative capacity of circulating polymorphonuclear neutrophils (PMNs) in non-diabetic NASH patients (with Timea Csak, Karen Kodys, Angela Dolganiuc, Dora Lippai, Michal Ganz, and Christopher Marshall), Clinical and Translational Science Research Retreat (2012)
 

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Serum microRNA-122 and miR-155 as biomarkers of liver injury and inflammation in models of acute and chronic liver disease (with Shashi Bala, Jan Petrasek, Shiv Mundkur, Donna Catalano, Jeanine Ward, Ivan Levin, Hawau Alao, and Karen Kodys), Clinical and Translational Science Research Retreat (2012)