Articles
Insulin-Regulated Srebp-1c and Pck1 mRNA Expression in Primary Hepatocytes from Zucker Fatty but Not Lean Rats Is Affected by Feeding Conditions (with Yan Zhang, Wei Chen, Rui Li, Yang Li, and Yuebin Ge), PLoS ONE (2011)
Insulin regulates the transcription of genes for hepatic glucose and lipid metabolism. We hypothesized that...
Berberine Regulated Gck, G6pc, Pck1 and Srebp-1c Expression and Activated AMP-activated Protein Kinase in Primary Rat Hepatocytes (with Yuebin Yuebin, Yan Zhang, Rui Li, Wei Chen, and Yang Li), International Journal of Biological Sciences (2011)
The effects of hormonal and dietary stimuli on hepatic glucose and lipid homeostasis include regulation...
Retinoids induced Pck1 expression and attenuated insulin-mediated suppression of its expression via activation of retinoic acid receptor in primary rat hepatocytes (with Y Zhang, R Li, W Chen, and Y Li), Molectular and Cellular Biochemistry (2011)
Insulin regulates the expression of genes involved in hepatic glucose and lipid metabolism, such as...
Retinoids synergized with insulin to induce Srebp-1c expression and activated its promoter via the two liver X receptor binding sites that mediate insulin action (with R Li, W Chen, Y Li, and Y Zhang), Biochemical and Biophysical Research Communications (2011)
We have reported that the rat liver lipophilic extract (LE) synergized with insulin to induce...
Retinoids synergize with insulin to induce hepatic Gck expression., Nutrition Publications and Other Works (2009)
Hepatic GK (glucokinase) plays a key role in maintaining glucose homoeostasis. Many stimuli regulate GK...
Liver lipid molecules induce PEPCK-C gene transcription and attenuate insulin action., Nutrition Publications and Other Works (2007)
Cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) plays key roles in gluconeogenesis, glyceroneogenesis, and cataplerosis. Experiments were designed...
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice., Nutrition Publications and Other Works (2007)
Liver X receptors (LXRs) are nuclear receptors that play crucial roles in lipid metabolism in...
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver., Nutrition Publications and Other Works (2004)
Transcription of the gene encoding sterol regulatory element-binding protein 1c (SREBP-1c) is known to be...
Discrete and Complementary Mechanisms of Protection of β-Cells Against Cytokine-Induced and Oxidative Damage Achieved by bcl-2 Overexpression and a Cytokine Selection Strategy (with Veronique Vien Tran, Christopher B. Newgard, and Hans E. Hohmeier), Diabetes (2003)
We have been investigating the potential utility of engineered cell lines as surrogates for primary...
Inflammatory Mechanisms in Diabetes: Lessons from the B-cell (with H. E. Hohmeier, V. V. Tran, R. Gasa, and C. B. Newgard), International Journal of Obesity (2003)
Inflammation plays an important role in the destruction of pancreatic islet B-cells that leads to...
Control of Hepatic Gluconeogenesis through the Transcriptional Coactivator PGC-1 (with J. Cliff Yoon, Pere Puigserver, Jerry Donovan, Zhidan Wu, James Rhee, Guillaume Adelmant, John Stafford, C. Ronald Kahn, Daryl K. Granner, Christopher B. Newgard, and Bruce M. Spiegelman), Nature (2001)
Blood glucose levels are maintained by the balance between glucose uptake by peripheral tissues and...
Expression of the Transcription Factor STAT-1α in Insulinoma Cells Protects against Cytotoxic Effects of Multiple Cytokines (with Hans E. Hohmeier and Christopher B. Newgard), Journal of Biological Chemistry (2001)
Destruction of pancreatic islet β-cells in type 1 diabetes appears to result from direct contact...
Selection of Insulinoma Cell Lines with Resistance to Interleukin-1beta- and Gamma-interferon-induced Cytotoxicity (with H. E. Hohmeier, R. Gasa, V. V. Tran, and C. B. Newgard), Diabetes (2000)
Engineered insulinoma cell lines may represent an alternative to isolated islets for transplantation therapy of...
Isolation of INS-1-derived Cell Lines with Robust ATP-sensitive K+ Channel-dependent and -independent Glucose-stimulated Insulin Secretion (with H. E. Hohmeier, H. Mulder, R. Henkel-Rieger, M. Prentki, and C. B. Newgard), Diabetes (2000)
The biochemical mechanisms involved in regulation of insulin secretion are not completely understood. The rat...
Resistance to Adenovirally Induced Hyperleptinemia in Rats (with Kazunori Koyama, Michio Shimabukuro, May-Yun Wang, Young Lee, Pushpa S. Kalra, Michael J. Dube, Satya P. Kalra, Christopher B. Newgard, and Roger H. Unger), Journal of Clinical Investigation (1998)
Leptin regulates appetite and body weight via hypothalamic targets, but it can act directly on...
Beta-cell Function in Normal Rats Made Chronically Hyperleptinemic by Adenovirus-leptin Gene Therapy (with K. Koyama, M. Y. Wang, Y. Lee, M. Shimabukuro, C. B. Newgard, and R. H. Unger), Diabetes (1997)
Leptin was overexpressed in the liver of normal Wistar rats by infusing recombinant adenovirus containing...
Direct Antidiabetic Effect of Leptin through Triglyceride Depletion of Tissues (with Michio Shimabukuro, Kazunori Koyama, May-Yun Wang, Falguni Trieu, Young Lee, Christopher B. Newgard, and Roger H. Unger), Proceedings of the National Academy of Sciences of the United States of America (1997)
Leptin is currently believed to control body composition largely, if not entirely, via hypothalamic receptors...
Tissue Triglycerides, Insulin Resistance, and Insulin Production: Implications for Hyperinsulinemia of Obesity (with Kazunori Koyama, Young Lee, and Roger H. Unger), American Journal of Physiology - Endocrinology and Metabolism (1997)
Obesity is associated with both insulin resistance and hyperinsulinemia. Initially hyperinsulinemia compensates for the insulin...
Disappearance of Body Fat in Normal Rats Induced by Adenovirus-mediated Leptin Gene Therapy (with Kazunori Koyama, Xue Yuan, Young Lee, Yan-Ting Zhou, Robert O’Doherty, Christopher B. Newgard, and Roger H. Unger), Proceedings of the National Academy of Sciences of the United States of America (1996)
Sustained hyperleptinemia of 8 ng/ml was induced for 28 days in normal Wistar rats by...