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Selected Works of Guna S. Selvaduray
Article
Enhanced bone cells growth and proliferation on TiO2 nanotubular substrates treated by rf plasma discharge
Advanced Engineering Materials (2010)
  • Meena Mahmood, University of Arkansas at Little Rock
  • Philip Fejleh, University of Arkansas at Little Rock
  • Alokita Karmakar, University of Arkansas at Little Rock
  • Ashley Fejleh, University of Arkansas at Little Rock
  • Yang Xu, University of Arkansas at Little Rock
  • Ganesh Kannarpady, University of Arkansas at Little Rock
  • Hidetaka Ishihara, University of Arkansas at Little Rock
  • Rajesh sharma, Arkansas State University
  • Zhongrui Li, University of Arkansas at Little Rock
  • Guna S Selvaduray, San José State University
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Abstract
Titanium implants are well known for their biocompatibility, especially if bioinertness is desired, due to the TiO2 native oxide which is thermodynamically and chemically very stable. One of the major problems with this material involve its inability to induce enhanced cellular adhesion and proliferation on its surface without complicated structural approaches, leading to the possible lack of bone‐implant interfacial interaction and rejection. In order to potentially improve osseointegration of such implants self‐assembled vertical and ordered nanotubular TiO2 arrays were fabricated by electrochemical anodization and were plasma treated under O2, N2, O2 + N2, and He gaseous environments and their properties analyzed by various analytical procedures. Osteoblast bone cells (MC3T3‐E1) were grown on TiO2 nanotube‐arrayed substrates and their proliferation was analyzed and quantified. Oxygen and nitrogen plasma treatments were found to significantly improve the proliferation of the bone cells over the TiO2 nanoarray substrates, with the O2 + N2 combination yielding the most significant improvements. These findings may be explained by the interactions between the cells and the changes in the surface chemistry induced by the O2 and N2 groups introduced by the plasma discharge treatment onto the TiO2 surfaces
Keywords
  • osteoblast cell proliferation,
  • plasma treatment,
  • TiO2 nanotubes
Disciplines
Publication Date
November 11, 2010
Citation Information
Meena Mahmood, Philip Fejleh, Alokita Karmakar, Ashley Fejleh, et al.. "Enhanced bone cells growth and proliferation on TiO2 nanotubular substrates treated by rf plasma discharge" Advanced Engineering Materials Vol. 7 (2010) p. 5409 - 5418
Available at: http://works.bepress.com/guna_selvaduray/119/