Sustained research and development efforts culminating in the emergence of new and improved titanium alloys have provided both the impetus and interest for studying their mechanical behavior under the extrinsic influence of loading spanning both static and dynamic. In this article, the quasi-static and cyclic fatigue fracture behavior of a titanium alloy (Ti-Al-V-Fe-O2) is highlighted. Test specimens of this titanium alloy were deformed both in quasi-static tension and cyclic stress amplitude–controlled fatigue. The quasi-static mechanical properties, cyclic fatigue response and microscopic mechanisms contributing to deformation and eventual fracture are highlighted in light of the competing and mutually interactive influences of nature of loading, intrinsic microstructural effects, deformation characteristics of the titanium alloy metal matrix and macroscopic aspects of fracture.