If PHSSR is to realize its full potential in guiding the transformation of the US public health system, it will require “open science” mechanisms for accelerating the production and distribution of highly nuanced research findings about public health delivery. Currently, public health delivery systems are changing at a rate that far outpaces traditional research production and distribution cycles, resulting in many missed opportunities for studying and learning from these natural experiments. Mechanisms are needed for rapidly sharing research methodologies and data with other scholars in the field, and for rapidly communicating research results to decision-makers within public health delivery systems.