Mental health professionals worldwide realize the imperative for reducing inpatient restraints and seclusion. The high incidence of posttraumatic stress disorder for inpatients and the resulting symptoms support the creation of a trauma-informed approach. The objective of the current article is to describe the experience of staff in a 20-bed unit transitioning from traditional inpatient care to a trauma-informed approach. The study comprised a qualitative design using content analysis (n = 10). The patterns clustered into the following categories: changing perspective, developing collaborative relationships, implementing safety measures, and prescribing educational resources. Staff underwent a deep cultural change that subsequently won state recognition for the reduction of seclusion and restraints.