It is accepted worldwide that the dissolution of minerals in some cases, is an electrochemical process where anodic and cathodic reactions take place. There are many parameters, such as agent concentration, that directly affect the dissolution process. The rate of leaching of minerals may differ depending on the oxygen concentration. In this paper, the existence of anodic and cathodic zones on themineral surface during the dissolution/leaching of minerals andmetals has been presentedwith some differentworks. It isworthmentioning that a good number of published papers have experimentally demonstrated the existence of anodic and cathodic areas on the mineral surface.