Article
Identification of a Highly Specific Hydroxyapatite-binding Peptide using Phage Display
Advanced Materials
Document Type
Article
Publication Date
5-15-2008
Disciplines
Abstract
A peptide sequence SVSVGMKPSPRP that selectively recognizes hydroxyapatite (HA) is identified by using a phage display approach. The engineered sequence exhibits chemical and structural specificity for HA over calcium carbonate and HA's amorphous calcium phosphate precursor. In situ binding to HA in a tooth cross section further demonstrates the sequence specificity and utility in nondestructive imaging applications.
Citation Information
Marc D. Roy, Scott K. Stanley, Eric J. Amis and Matthew Becker. "Identification of a Highly Specific Hydroxyapatite-binding Peptide using Phage Display" Advanced Materials Vol. 20 Iss. 10 (2008) p. 1830 - 1836 Available at: http://works.bepress.com/eric_amis/1/