Our laboratory takes an enormously multidisciplinary approach to the study of the interface between biology and nanotechnology (or, more generally, life and technology). This area of inquiry can be labeled either bionanotechnology or synthetic biology. The label is of no importance. What is important is that 3.6 billion years of biological evolution has resulted a vast library of deeply tested pathways to addressing the dreams of nanotechnology. Our challenge is to understand and, in a practical fashion, transfer these insights to the emerging field of bionanotechnology. Our research team has developed a complex, multidimensional mechanical system made out of DNA for testing molecular bonds and detecting molecular species. We have also developed enhancements to the process of DNA origami that expand the opportunity space for DNA-based nanosystems substantially. Additional ongoing projects involve “shape-shifting” DNA nanodevices and computational methods for generating the tools required to fully exploit the potential of DNA-based nanosystems.