My lab is conducting two distinct research projects. In the first project, we are investigating the mechanisms that control the uptake and homeostasis of iron. This project has important implications both for our basic understanding of these mechanisms, and also for our ability to manipulate the iron content of particular plant parts as a means of improving the iron nutritional quality of food. In the second project, we are using molecular approaches to discover genes involved in production of paclitaxel (generic name for Taxol™ - Bristol-Myers Squibb). Genes discovered during this project will improve our ability to supply sufficient quantities of paclitaxel to the world.
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Identification and expression analysis of methyl jasmonate responsive ESTs in paclitaxel producing Taxus cuspidata suspension culture cells (with Sangram K. Lenka, Nadia Boutaoui, Bibin Paulose, Kham Vongpaseuth, Jennifer Normanly, and Susan C. Roberts), BMC Genomics (2012)
Background Taxol(R)(paclitaxel) promotes microtubule assembly and stabilization and therefore is a potent chemotherapeutic agent against...
Disruption of OsYSL15 Leads to Iron Inefficiency in Rice Plants (with S. Lee, J. C. Chiecko, Y. Lee, M. L. Guerinot, and G. An), Plant Physiology (2009)
Uptake and translocation of metal nutrients are essential processes for plant growth. Graminaceous species release...
Mutations in Arabidopsis Yellow Stripe-Like1 and Yellow Stripe-Like3 Reveal Their Roles in Metal Ion Homeostasis and Loading of Metal Ions in Seeds (with B. M. Waters, H. H. Chu, R. J. Didonato, L. A. Roberts, R. B. Eisley, B. Lahner, and D. E. Salt), Plant Physiology (2006)
Here, we describe two members of the Arabidopsis (Arabidopsis thaliana) Yellow Stripe-Like (YSL) family, AtYSL1...
Yellow Stripe1. Expanded Roles for the Maize Iron-Phytosiderophore Transporter (with L. A. Roberts, A. J. Pierson, and Z Panaviene), Plant Physiology (2004)
Graminaceous monocots, including most of the world's staple grains (i.e. rice, corn, and wheat) use...