In the 21st century, we talk of knowledge as the new currency, and knowledge building as the work to be done in learning organizations. While knowledge building is activity directed outward towards the creation of knowledge itself, learning is a personal consequence of this process, the aspect that is directed to enhancing individual abilities and dispositions. This chapter considers how ePortfolios can support four aspects of lifelong learning in the knowledge economy: engagement with technology, representations of identity, developing critical multiliteracies, and global and local mobility. It argues that the focus should be on lifelong learners’ capacity to create and communicate with digital technologies, rather than on rigid frameworks that reduce ePortfolio development to a series of pre-packaged choices.