Hormesis

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Historical foundations of wound healing and its potential, Wound Repair and Regeneration (2013)

ABSTRACT This paper provides a detailed historical assessment of the origin and developmental progress of...

 

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Predicting Low Dose Effects for Chemicals in High Through-Put Studies (with Edward J. Stanek, III Ph.D.), Dose-Response (2010)

High through-put studies commonly use automated systems with 96-well plates in which multiple chemicals are...

 

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Tumor Resistance Explained by Hormesis (with Marc A. Nascarella Ph.D.), Dose-Response (2010)

Enhanced drug (GDC 0449) resistance in a mouse model for human medulloblastoma is shown in...

 

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Quantification of Hormesis in Anticancer-Agent Dose-Response (with Marc A. Nascarella Ph.D.; Edward J. Stanek, III Ph.D.; and George R. Hoffmann Ph.D.), Dose-Response (2009)

Quantitative features of dose responses were analyzed for 2,189 candidate anticancer agents in 13 strains...

 

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Chloramphenicol, European Legislation and Hormesis - Commentary (with Jaap C. Hanekamp), Dose-Response (2007)
 

Wound Healing

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Historical foundations of wound healing and its potential, Wound Repair and Regeneration (2013)

ABSTRACT This paper provides a detailed historical assessment of the origin and developmental progress of...

 

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Stress Responses, Vitagenes and Hormesis as Critical Determinants in Aging and Longevity: Mitochondria as a “Chi” (with Carolin Cornelius, Rosario Perrotta, Antonio Graziano, and Vittorio Calabrese), Immunity and Ageing (2013)

Understanding mechanisms of aging and determinants of life span will help to reduce age-related morbidity...

 

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A Method to Evaluate Hormesis in Nanoparticle Dose-Responses (with Marc A. Nascarella Ph.D.), Dose-Response (2012)

The term hormesis describes a dose-response relationship that is characterized by a response that is...

 

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Hormesis and the Salk Polio Vaccine, Dose-Response (2012)

The production of the Salk vaccine polio virus by monkey kidney cells was generated using...

 

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The Role of X-Rays in the Treatment of Gas Gangrene: A Historical Assessment (with Gaurav Dhawan), Dose-Response (2012)

While the use of x-rays to treat patients with gas gangrene ended in the early...

 

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Exposure to Nanoparticles and Hormesis (with Ivo Iavicoli and Marc A. Nascarella Ph.D.), Dose-Response (2010)

Nanoparticles are particles with lengths that range from 1 to 100 nm. They are increasingly...

 

The Importance of Hormesis to Public Health (with Robert Cook), Environmental Health Perspectives (EHP) (2006)

Background: Hormesis is a specific type of nonmonotonic dose response whose occurrence has been documented...

 

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Hormesis and stage specific toxicity induced by cadmium in an insect model, the queen blowfly, Phormia regina Meig. (with Marc A. Nascarella; John G. Stoffolano, Jr.; Edward J. Stanek, III; and Paul T. Kostecki), Environ. Poll. (2003)
 

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Hormesis at the National Toxicology Program (NTP): Evidence of Hormetic Dose Response in NTP Dose-Range Studies (with Linda A. Baldwin), Nonlinearity in Biology, Toxicology, and Medicine (2003)

The National Toxicology Program (NTP) dose-ranging studies typically employ five dosages and a concurrent control...

 

Hormesis: The Dose-response Revolution (with Linda A. Baldwin), Annual Review of Pharmacology and Toxicology (2003)

Hormesis, a dose-response relationship phenomenon characterized by low-dose stimulation and high-dose inhibition, has been frequently...

 

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The Maturing of Hormesis as a Credible Dose-Response Model, Nonlinearity in Biology, Toxicology, and Medicine (2003)

Hormesis is a dose-response phenomenon that has received little recognition, credibility and acceptance as evidenced...

 

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U-Shaped Dose-Responses in Biology, Toxicology, and Public Health (with Linda A. Baldwin), Annual Review of Public Health (2001)

The occurrence of U-shaped dose-response relationships (often termed hormesis) has been documented in numerous biological,...

 

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Hormesis as a Biological Hypothesis (with Linda A. Baldwin), Environmental Health Perspectives (EHP) (1998)

A comprehensive effort was undertaken to identify articles demonstrating chemical hormesis. Nearly 4000 potentially relevant...

 

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Soil Ingestion: A Concern for Acute Toxicity in Children (with Edward J. Stanek, Robert C. James, and Stephen M. Roberts), Environmental Health Perspectives (EHP) (1997)

Several soil ingestion studies have indicated that some children ingest substantial amounts of soil on...

 

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Daily Estimates of Soil Ingestion in Children (with Edward J. Stanek, III), Environmental Health Perspectives (EHP) (1995)

Soil ingestion estimates play an important role in risk assessment of contaminated sites, and estimates...

 

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A Toxicological Basis to Derive a Generic Interspecies Uncertainty Factor (with Linda A. Baldwin), Environmental Health Perspectives (EHP) (1994)

The use of an uncertainty factor (UF) to account for interspecies variation in risk assessment...

 

Risk Assessment and Environmental Fate Methodologies (with Paul T. Kostecki), Paul T. Kostecki (1992)